Eduki publikatzailea

HE-CRISPRGels

CRISPRGels: Rational Nanoparticle Design for Efficient Transmucosal CRISPR Delivery in Cystic Fibrosis

Specific programme: HE-MSCA-PF-EF23/09 

 
UPV/EHU Partner Status: Beneficiary
UPV/EHU PI:  Marcelo Calderón

Project start: 01/09/2024 
Project end: 28/02/2027

Brief description:

Cystic fibrosis (CF) is the most common genetic lung disease (monogenic autosomal recessive disorder) worldwide and currently there is no cure. The emergence of powerful gene editing tools like CRISPR-Cas (“clustered regularly interspaced short palindromic repeats/ associated protein 9”), now provides the opportunity to correct the disease-causing mutations which can potentially cure CF. The present research project proposes the development of core-multishell nanogels (NGs) yielding efficient transmucosal delivery of CRISPR-based gene editing tools which can address the challenges for treatment of CF at European level. This project brings together a talented,

highly motivated and young Researcher (Dr. Krishan Kumar) with background in polymer chemistry (phase transition temperatures, understanding structure of colloids, bio-macromolecular interactions) and protein science (structural stability, immobilization, enzymatic activity); and an innovative institute POLYMAT in developing biomedical solutions for treating CF diseases based on nanogels mediated controlled release of CRISPR/Cas9 complex. CRISPRGels will focus on advancing the young researcher’s career through development and manufacture stages of non-viral gene delivery systems facilitating the curative gene editing approaches for treatment of CF patients.

The host supervisor Prof. Marcelo Calderón is globally recognized researcher working in area of transmucosal delivery using nanogels (NGs). The behavior and interactions of the NGs will be systematically investigated in CF patient-derived sputum and CF bronchial epithelial models. Most efficient NGs will be validated on pre-industrial scale. Multidisciplinary expertise required for CRISPRGels will be complemented by highly experienced research teams Responsive Polymer Therapeutics Group (RPTG), Translational Organ Models Group (TOMG) and i+Med company.

Introduction_ProjectsObtained

Projects obtained by the UPV/EHU in the Horizon 2020 Programme for Research and Innovation.

Marie Sklodowska Curie Individual Fellowships

Industrial Leadership (LEIT)

Societal Challenges

Info_Organizacion-participacion

Nazioarteko proiektuak UPV/EHUren partaidetzarekin (2014-2020) 

INTERREG V

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COST Actions

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LIFE Action Grants

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Joint Programming Initiatives (JPIs)

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ERA NET Initiatives

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ERASMUS Programme

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OTHER EUROPEAN & INTERNATIONAL RESEARCH PROGRAMMES

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OTHER RESEARCH PROGRAMMES

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Nazioarteko proiektuak UPV/EHUren partaidetzarekin (2007-2014)

 

SUMMARY OF EUROPEAN AND INTERNATIONAL RESEARCH PROJECTS AWARDED TO UPV/EHU (2007-2014)
Programa Azpi-programa Proiektuen zerrenda
7th Framework Programme (FP7) Cooperation Download (pdf, 245KB)
Capacities Download (pdf, 120KB)
People Download (pdf, 112KB)
Ideas Download (pdf, 100KB)
Interreg    Download (pdf, 700KB)
Competitiveness and Innovation Programme (CIP) Download (pdf, 95KB)
Acciones COST Download (pdf, 105KB)
Otros Programas de Investigación Europeos e Internacionales Download (pdf, 138KB)

 

Info_MásInformaciónEHUrOPE

Gehiago jakiteko:

Nazioarteko I+G Bulegoa UPV/EHU
Posta elektronikoa: europarproiektuak@ehu.es