Telefonoa: 94 601 8072
Posta elektronikoa: josean.rodriguez@ehu.es
Bulegoaren kokapena: Medikuntza eta Erizaintza Fakultatea am 7.2 bulegoa
Ikerketa Taldea: MINBIZIAREN BIOLOGIA MOLEKULARRA

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2007tik aurrera Medikuntza eta Odontologia Fakultateko irakaslea naiz Euskal Herriko Unibertsitatean (UPV/EHU). Nire dozentzia ondoko irakasgaietan ematen dut: Medical Genetics, Ikerketa Biomedikorako Sarrera eta Ikerketa Proiektua. Horrez gain, graduondoko dozentziari dagokionez, Molecular Bases of Cell Proliferation, Differentiation and Death irakasgaia eman eta kordinatzen dut, UPV/EHUketa Cantabria Unibertsitateak batera eskeintzen duten Biologia Molekularra eta Biomedikuntza Masterrean.

UPV/EHUra etorri aurretik (2001-2006) Vrije Universiteit Amsterdam-go Onkologia Medikuko sailean irakatsi nuen. Bertan Onkologia Masterrean parte hartu nuen eta ikasleen lanak zuzendu nituen.

1998an Euskal Herriko Unibertsitatean (UPV/EHU) doktore gradua lortu nuen "Factores genéticos en la carcinogénesis cervical inducida por el virus HPV" tesiarekin. Tesia bukatu ostean Eusko Jaurlaritzaren Doktorego osteko beka lortuta Sydney-ko Westmead Institute for Cancer Research-era joan nintzen ikertzera. Bederatzi urtez minbizaren transformazioaren inguruko prozezu molekularrak ikertzen aritu nintzen hainbat herritako ikerketa zentruetan, Herbeheretan, EEBBn eta Australian. 50 ikerketa artikulu baino gehiago argitaratu ditut  eta 4 tesi zuzendu ditut eta beste bi zuzentzen ari naiz.

2007 urtean UPV/EHUra bueltatu eta gero Euskadiko Zientzia eta Teknologia Sistemara batu nintzen. MICINN eta Eusko Jaurlaritzako Saiotek eta Etortek programak eta unibertsitateko proiektuei esker minbiziaren prozesu molekularrak aztertzen dituen ikerketa lerro bat garatu dut. Gure lana proteinen ubikitinazioan eta garraio nukleozioplasmikoan zentratzen da. Gure helburua minbiziaren osaketarako zuzendutako terapia berriak garatzea da.

UPV/EHUko Agente Biologikoen eta Genetikoki Eraldatutako Organismoen Ikerketetarako Etika Batzordeko kidea, eta Asociación Española de Investigación sobre el Cáncer (ASEICA) elkarteko juntakidea naiz.

Ikerketa talde nazional nahiz internazionalekin lankidetzan dihardut eta gure taldea ‘European COST Action (Proteastasis)' delakoaren parte da. Talde hau berriki jarri da martxan eta ubikitinazioarekin erlazionaturiko prozesuen azterketan parte hartzen duten ikerketa taldeez osatuta dago.

1: Prieto G, Rodríguez JA, Fullaondo A. Enhancing prediction of short linear
protein motifs with Wregex 3.0. Comput Struct Biotechnol J. 2024 Jul
17;23:2978-2984. doi: 10.1016/j.csbj.2024.07.013. PMID: 39135888; PMCID:
PMC11318550.

2: Chaudhry S, Beckedorff F, Jasdanwala SS, Totiger TM, Affer M, Lawal AE,
Montoya S, Tamiro F, Tonini O, Chirino A, Adams A, Sondhi AK, Noudali S,
Cornista AM, Nicholls M, Afaghani J, Robayo P, Bilbao D, Nimer SD, Rodríguez JA,
Bhatt S, Wang E, Taylor J. Altered RNA export by SF3B1 mutants confers
sensitivity to nuclear export inhibition. Leukemia. 2024 Sep;38(9):1894-1905.
doi: 10.1038/s41375-024-02328-1. Epub 2024 Jul 13. PMID: 38997434; PMCID:
PMC11347370.

3: Arroyo-Berdugo Y, Sendino M, Greaves D, Nojszewska N, Idilli O, So CW, Di
Silvio L, Quartey-Papafio R, Farzaneh F, Rodriguez JA, Calle Y. High Throughput
Fluorescence-Based In Vitro Experimental Platform for the Identification of
Effective Therapies to Overcome Tumour Microenvironment-Mediated Drug Resistance
in AML. Cancers (Basel). 2023 Mar 27;15(7):1988. doi: 10.3390/cancers15071988.
PMID: 37046649; PMCID: PMC10093176.

4: Barroso-Gomila O, Muratore V, Merino-Cacho L, Rodriguez JA, Barrio R,
Sutherland JD. Studying the ubiquitin code through biotin-based labelling
methods. Semin Cell Dev Biol. 2022 Dec;132:109-119. doi:
10.1016/j.semcdb.2022.02.009. Epub 2022 Feb 16. PMID: 35181195.

5: Elu N, Osinalde N, Ramirez J, Presa N, Rodriguez JA, Prieto G, Mayor U.
Identification of substrates for human deubiquitinating enzymes (DUBs): An up-
to-date review and a case study for neurodevelopmental disorders. Semin Cell Dev
Biol. 2022 Dec;132:120-131. doi: 10.1016/j.semcdb.2022.01.001. Epub 2022 Jan 15.
PMID: 35042675.

6: Giordano I, Pirone L, Muratore V, Landaluze E, Pérez C, Lang V, Garde-Lapido
E, Gonzalez-Lopez M, Barroso-Gomila O, Vertegaal ACO, Aransay AM, Rodriguez JA,
Rodriguez MS, Sutherland JD, Barrio R. SALL1 Modulates CBX4 Stability, Nuclear
Bodies, and Regulation of Target Genes. Front Cell Dev Biol. 2021 Sep
21;9:715868. doi: 10.3389/fcell.2021.715868. PMID: 34621739; PMCID: PMC8490708.

7: López DJ, Rodríguez JA, Bañuelos S. Molecular Mechanisms Regulating the DNA
Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain. Int J Mol
Sci. 2021 Jun 11;22(12):6308. doi: 10.3390/ijms22126308. PMID: 34208390; PMCID:
PMC8231204.

8: Ramirez J, Prieto G, Olazabal-Herrero A, Borràs E, Fernandez-Vigo E,
Alduntzin U, Osinalde N, Beaskoetxea J, Lectez B, Aloria K, Rodriguez JA,
Paradela A, Sabidó E, Muñoz J, Corrales F, Arizmendi JM, Mayor U. A Proteomic
Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes.
Int J Mol Sci. 2021 May 3;22(9):4851. doi: 10.3390/ijms22094851. PMID: 34063716;
PMCID: PMC8124392.

9: Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Martín-Martín N, Ercilla
A, Rodríguez JA, Carracedo A, Sutherland JD, Barrio R. LUZP1 Controls Cell
Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton.
Front Cell Dev Biol. 2021 Apr 1;9:624089. doi: 10.3389/fcell.2021.624089. PMID:
33869174; PMCID: PMC8049182.

10: Olazabal-Herrero A, Bilbao-Arribas M, Carlevaris O, Sendino M, Varela-
Martinez E, Jugo BM, Berra E, Rodriguez JA. The dystrophia myotonica WD repeat-
containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.
FEBS J. 2021 Oct;288(20):5943-5963. doi: 10.1111/febs.15875. Epub 2021 Apr 28.
PMID: 33844468.

11: Urizar-Arenaza I, Benedicto A, Perez-Valle A, Osinalde N, Akimov V, Muñoa-
Hoyos I, Rodriguez JA, Asumendi A, Boyano MD, Blagoev B, Kratchmarova I, Subiran
N. The multifunctional role of SPANX-A/D protein subfamily in the promotion of
pro-tumoural processes in human melanoma. Sci Rep. 2021 Feb 11;11(1):3583. doi:
10.1038/s41598-021-83169-1. PMID: 33574425; PMCID: PMC7878863.

12: Rodriguez JA. The "STK38-XPO1 axis": its general relevance and mechanistic
underpinnings remain to be further characterized. Cell Mol Life Sci. 2021
May;78(9):4451-4452. doi: 10.1007/s00018-021-03778-x. Epub 2021 Feb 9. PMID:
33559690; PMCID: PMC11072521.

13: Olazagoitia-Garmendia A, Zhang L, Mera P, Godbout JK, Sebastian-DelaCruz M,
Garcia-Santisteban I, Mendoza LM, Huerta A, Irastorza I, Bhagat G, Green PH,
Herrero L, Serra D, Rodriguez JA, Verdu EF, He C, Bilbao JR, Castellanos-Rubio
A. Gluten-induced RNA methylation changes regulate intestinal inflammation via
allele-specific <i>XPO1</i> translation in epithelial cells. Gut. 2022
Jan;71(1):68-76. doi: 10.1136/gutjnl-2020-322566. Epub 2021 Feb 1. PMID:
33526437; PMCID: PMC8666699.

14: Sendino M, Omaetxebarria MJ, Prieto G, Rodriguez JA. Using a Simple Cellular
Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into
CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides. Int J Mol
Sci. 2020 Sep 1;21(17):6341. doi: 10.3390/ijms21176341. PMID: 32882917; PMCID:
PMC7503480.

15: López DJ, Rodríguez JA, Bañuelos S. Nucleophosmin, a multifunctional
nucleolar organizer with a role in DNA repair. Biochim Biophys Acta Proteins
Proteom. 2020 Dec;1868(12):140532. doi: 10.1016/j.bbapap.2020.140532. Epub 2020
Aug 25. PMID: 32853771.

16: Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Bermejo-Arteagabeitia
A, Da Fonseca C, Barroso-Gomila O, Azkargorta M, Iloro I, Pampliega O, Andrade
R, Martín-Martín N, Branon TC, Ting AY, Rodríguez JA, Carracedo A, Elortza F,
Sutherland JD, Barrio R. LUZP1, a novel regulator of primary cilia and the actin
cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. Elife. 2020
Jun 18;9:e55957. doi: 10.7554/eLife.55957. PMID: 32553112; PMCID: PMC7363444.

17: Urizar-Arenaza I, Osinalde N, Akimov V, Puglia M, Muñoa-Hoyos I, Gianzo M,
Rodriguez JA, Ganzabal T, Blagoev B, Kratchmarova I, Subiran N. SPANX-A/D
protein subfamily plays a key role in nuclear organisation, metabolism and
flagellar motility of human spermatozoa. Sci Rep. 2020 Mar 27;10(1):5625. doi:
10.1038/s41598-020-62389-x. PMID: 32221341; PMCID: PMC7101357.

18: Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila
EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue
D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK,
Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O. Altered
Nuclear Export Signal Recognition as a Driver of Oncogenesis. Cancer Discov.
2019 Oct;9(10):1452-1467. doi: 10.1158/2159-8290.CD-19-0298. Epub 2019 Jul 8.
PMID: 31285298; PMCID: PMC6774834.

19: Elu N, Osinalde N, Beaskoetxea J, Ramirez J, Lectez B, Aloria K, Rodriguez
JA, Arizmendi JM, Mayor U. Detailed Dissection of UBE3A-Mediated DDI1
Ubiquitination. Front Physiol. 2019 May 3;10:534. doi: 10.3389/fphys.2019.00534.
PMID: 31130875; PMCID: PMC6509411.

20: Olazabal-Herrero A, Sendino M, Arganda-Carreras I, Rodríguez JA. WDR20
regulates shuttling of the USP12 deubiquitinase complex between the plasma
membrane, cytoplasm and nucleus. Eur J Cell Biol. 2019 Jan;98(1):12-26. doi:
10.1016/j.ejcb.2018.10.003. Epub 2018 Nov 3. PMID: 30466959.