MSCA programme in HE

Marie Skłodowska-Curie Actions

The Marie Skłodowska-Curie Actions fund excellent research and innovation and equip researchers at all stages of their career with new knowledge and skills, through mobility across borders and exposure to different sectors and disciplines. The MSCA help build Europe’s capacity for research and innovation by investing in the long-term careers of excellent researchers.

The MSCA also fund the development of excellent doctoral and postdoctoral training programmes and collaborative research projects worldwide. By doing so, they achieve a structuring impact on higher education institutions, research centres and non-academic organisations.

The MSCA promote excellence and set standards for high-quality researcher education and training in line with the European Charter for Researchers and the Code of Conduct for the recruitment of researchers.

There are 5 types of MSCA targeting different objectives.

  • Doctoral Networks (DN)
    Supporting programmes to train doctoral candidates in academic and non-academic organisations.
  • Postdoctoral Fellowships (PF)
    Supporting career perspectives and excellence of postdoctoral researchers.
  • Staff Exchanges (SE)
    Encouraging collaborations between organisations through staff exchanges.
  • COFUND
    Co-funding of regional, national and international programmes.
  • MSCA and Citizens
    Bringing research and researchers closer to the public at large.

More information on the Marie Skłodowska-Curie Actions is available here.

MSCA Doctoral Networks (DN) Projects

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MSCA Postdoctoral Fellowships (PF) projects

CRISPRGels: Rational Nanoparticle Design for Efficient Transmucosal CRISPR Delivery in Cystic Fibrosis

Specific programme: HE-MSCA-PF-EF23/09 

 
UPV/EHU Partner Status: Beneficiary
UPV/EHU PI:  Marcelo Calderón

Project start: 01/09/2024 
Project end: 28/02/2027

Brief description:

Cystic fibrosis (CF) is the most common genetic lung disease (monogenic autosomal recessive disorder) worldwide and currently there is no cure. The emergence of powerful gene editing tools like CRISPR-Cas (“clustered regularly interspaced short palindromic repeats/ associated protein 9”), now provides the opportunity to correct the disease-causing mutations which can potentially cure CF. The present research project proposes the development of core-multishell nanogels (NGs) yielding efficient transmucosal delivery of CRISPR-based gene editing tools which can address the challenges for treatment of CF at European level. This project brings together a talented,

highly motivated and young Researcher (Dr. Krishan Kumar) with background in polymer chemistry (phase transition temperatures, understanding structure of colloids, bio-macromolecular interactions) and protein science (structural stability, immobilization, enzymatic activity); and an innovative institute POLYMAT in developing biomedical solutions for treating CF diseases based on nanogels mediated controlled release of CRISPR/Cas9 complex. CRISPRGels will focus on advancing the young researcher’s career through development and manufacture stages of non-viral gene delivery systems facilitating the curative gene editing approaches for treatment of CF patients.

The host supervisor Prof. Marcelo Calderón is globally recognized researcher working in area of transmucosal delivery using nanogels (NGs). The behavior and interactions of the NGs will be systematically investigated in CF patient-derived sputum and CF bronchial epithelial models. Most efficient NGs will be validated on pre-industrial scale. Multidisciplinary expertise required for CRISPRGels will be complemented by highly experienced research teams Responsive Polymer Therapeutics Group (RPTG), Translational Organ Models Group (TOMG) and i+Med company.

MSCA Staff Exchanges (SE) projects

MSCA COFUND projects

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MSCA and Citizens projects