Grupo de Investigación en:
Radicales Libres y Estrés Oxidativo en la Fisiopatología Humana
Departamento de Fisiología
Facultad de Medicina y Enfermería, Universidad del País Vasco, UPV/EHU
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Publicaciones

• Pérez-Ruiz I, Ruiz-Sanz JI, Hernández ML, Navarro R, Ferrando M, Larreategui Z, Ruiz-Larrea MB. Evidence of paraoxonases 1, 2, and 3 expression in human ovarian granulosa cells. Antioxidants 10 (10), 1504: 1-16, 2021. DOI https://doi.org/10.3390/antiox10101504.

• Aja I, Krisa S, Hornedo-Ortega R, Ruiz-Larrea MB, Ruiz-Sanz JI, Richard T, Courtois A. Stilbenes at low micromolar concentrations mitigate the NO, TNF-a, IL-1β and ROS production in LPS-stimulated murine macrophages. Journal of Biologically Active Products from Nature (JBAPN) 11(3): 212-222, 2021. DOI: https://doi.org/10.1080/22311866.2021.1923571.

• Aja I, Ruiz-Larrea MB, Courtois A, Krisa s, Richard T, Ruiz-Sanz JI. Screening of natural stilbene oligomers from Vitis vinifera for anticancer activity on human hepatocellular carcinoma cells. Antioxidants 9,469:1-14, 2020. DOI:https://doi.org/10.3390/antiox9060469

• Matorras R, Exposito A, Ferrando M, Mendoza R, Larreategui Z, Lainz L, Aramburu L, Andrade F, Aldámiz-Echevarria L, Ruiz-Larrea MB, Ruiz-Sanz JI. Obese and overweight women have lower amounts of n-3 polyunsaturated fatty acids in their oocytes than women with normal weight. Fertil Steril 113: 53-61, 2020. DOI:https://doi.org/10.1016/j.fertnstert.2019.08.059.

• Fernández-Eulate G, Ruiz-Sanz JI, Riancho J, Zufiría M, Gereñu G, Fernández-Torrón R, Poza-Aldea JJ, Ondaro J, Espinal JB, González-Chinchón G, Zulaica M, Ruiz-Larrea MB, López de Munain A, Gil-Bea FJ. A comprehensive serum lipidome profiling of amyotrophic lateral sclerosis. Amyotroph Lat Scl Fr 21:252-262, 2020. DOI:10.1080/21678421.2020.1730904.

• Prieto I, Rubio Alarcón C, García-Gómez R, Portero M, Pamplona R, Martinez-Ruiz A, Ruiz-Sanz JI, Ruiz-Larrea MB, Jove M, Cerdán S, Monsalve M. Metabolic adaptations in spontaneously immortalized PGC-1a knock-out MEF increase their oncogenic potential. Redox Biol 29:101396:1-13, 2020. DOI:10.1016/j.redox.2019.101396.

• Aja I, Azib L, Da Costa G, Pedrot E, Iglesias ML, Palos-Pinto A, Valls J, Chaher N, Ruiz-Larrea MB, Mérillon JM, Atmani D, Ruiz-Sanz JI, Richard T. Unusual stilbene glucosides from Vitis vinifera roots. OENO One, 3: 573-579, 2019. DOI:https://doi.org/10.20870/oeno-one.2019.53.3.2462  

• Pérez-Ruiz I, Meijide S, Ferrando M, Larreategui Z, Ruiz-Larrea MB, Ruiz-Sanz JI. Ovarian stimulated cycles reduce protection of follicular fluid against free radicals. Free Radic Biol Med 145: 330-335, 2019. DOI:10.1016/j.freeradbiomed.2019.10.004

• Segarra AB, Prieto I, Martínez-Cañamero M, Ruiz Sanz JI, Ruiz-Larrea MB, DeGasparo M, Banegas I, Zorad S, Ramírez-Sanchez M. Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depnding on fish, oilive or coconut oil used in the diet. Endocrine Regulations 53:59-64, 2019. DOI:10.2478/enr-2019-0007

• Matorras R, Lainz L, Ruiz-Sanz JI, Ruiz-Larrea MB. Estrés oxidativo y reproducción asistida. En Avances en Fertilidad. “Fecundación in vitro: claves para mejorar nuestra estrategia terapéutica” JJ Espinós Gómez. Ed. Glosa S.L. Barcelona, 2018. ISBN:978-84-7429-704-1.

• Ruiz-Sanz JI, Pérez-Ruiz I, Meijide S, Ferrando M, Larreategui Z, Ruiz-Larrea MB. Lower follicular n-3 polyunsaturated fatty acid levels are associated with a better response to ovarian stimulation. J Assist Reprod Genet. 36: 473-482, 2019. DOI: 10.1007/s10815-018-1384-1.

• Pérez-Ruiz I, Meijide S, Hernández ML, Navarro R, Larreategui Z, Ferrando M, Ruiz-Larrea MB, Ruiz-Sanz JI. Analysis of protein oxidative modifications in follicular fluid from fertile women: natural versus stimulated cycles. Antioxidants 7, pii: E176. 2018. DOI: 10.3390/antiox7120176.

• Ruiz-Larrea MB. Breve historia de los radicales libres. DOI:http://dx.doi.org/10.18567/sebbmdiv_RPC.2018.04.1, SEBBM Divulgación, abril 2018.

• Ruiz-Larrea MB. Rebeca Gerschman (1903-1986). SEBBM Divulgación, Galería de retratos Women in Biochemistry, marzo 2018.  DOI:http://dx.doi.org/10.18567/sebbmdiv_RMB.2018.03.1 marzo 2018. 

• Trepiana J, Ruiz-Sanz JI, Ruiz-Larrea MB. Unraveling the in vitro antitumor activity of Vismia baccifera against HepG2: role of hydrogen peroxide. Heliyon 4:e00675 (1-20), 2018. DOI: 10.1016/j.heliyon.2018.e00675.

• Ruiz-Larrea MB. Rebeca Gerschman: una bioquímica argentina adelantada a su tiempo. Blog Mujeres con Ciencia, Cátedra de Cultura Científica, UPV/EHU. DOI:https://mujeresconciencia.com/2017/12/05/rebeca-gerschman-una-bioquimica-argentina-adelantada-tiempo/.  5 de diciembre 2018.

• Martínez-Feito A, Plasencia-Rodriguez C, Navarro-Compán V, Jurado T, Kneepkens EL, Wolbink GJ, Martín S, Ruiz Del Agua A, Navarro R, Mezcua A, Jochems A, Peiteado D, Bonilla MG, Balsa A, Pascual-Salcedo D. Optimal concentration range of golimumab in patients with axial spondyloarthritis. Clin Exp Rheumatol Sep 15, 2017.

• Meijide S, Pérez-Ruiz I, Hernández ML, Navarro R, Ferrando M, Larreategui Z, Ruiz-Sanz JI, Ruiz-Larrea MB. Paraoxonase activities in human follicular fluid: role in follicular maturation and fertility. Reprod Biomed Online 35:351-362, 2017. DOI: 10.1016/j.rbmo.2017.06.008.

• Ajuria-Morentín I, Mar-Medina C, Aguirre Larracoechea U, Quintana-López JM, Ruiz-Larrea MB, Cortés Fernández C. Change in the reference values for serum vitamin B12: Impact on the clinical laboratory. Clin Lab 62:2469-2471, 2016. DOI:10.7754/Clin.Lab.2016.160519.

• Trepiana J, Meijide S, Navarro R, Hernández ML, Ruiz-Sanz JI, Ruiz-Larrea MB. Influence of oxygen partial pressure on the characteristics of human hepatocarcinoma cells. Redox Biol 12: 103-113, 2017. DOI:org/10.1016/j.redox.2017.02.004.

• Martín S, del Agua AR, Torres N, Pascual-Salcedo D, Plasencia C, Ruiz-Argüello B, Martínez A, Navarro R, Nagore D. Comparison study of two commercially available methods for the determination of golimumab and anti-golimumab antibody levels in patients with rheumatic diseases. Clin Chem Lab Med. 53:e297-9, 2015.

• Lizcano LJ, Siles M, Trepiana J, Hernández ML, Navarro R, Ruiz-Larrea MB, Ruiz-Sanz JI. Piper and Vismia species from Colombian Amazonia differentially affect cell proliferation of hepatocarcinoma cells. Nutrients 7: 179-195, 2014. DOI:10.3390/nu7010179.

• Ajuria-Morentín I, Mar-Medina C, Bereciartua- Urbieta E, Aguirre Larracoechea U, Quintana-López JM, Ruiz-Larrea MB. Determination of reference values for serum folate and vitamin B12 using three different immunoassays: Is it worth making an effort to produce them in our laboratory? Clin Lab 60: 1135-1143, 2014.

• Lizcano LJ, Viloria-Bernal M, Vicente F, Berrueta LA, Gallo B, Martínez-Cañamero M, Ruiz-Larrea MB, Ruiz-Sanz JI. Lipid oxidation inhibitory effects and phenolic composition of aqueous extracts from medicinal plants of Colombian Amazonia. Int J. Mol. Sci 13: 5454-5467, 2012. DOI:10.3390/ijms13055454.

• Crisol L, Matorras R, Aspichueta F, Expósito A, Hernández ML, Ruiz-Larrea MB, Mendoza R, Ruiz-Sanz JI. Glutathione peroxidase activity in seminal plasma and its relationship with classical sperm parameters and IVF- ICSI outcome. Fertil Steril 97:852-857, 2012. 

• Segarra A, Ruiz-Sanz JI, Ruiz-Larrea MB, Ramírez-Sánchez M, de Gasparo M, Banegas I, Martínez-Cañamero M, Francisco Vives, Prieto I. The profile of fatty acids in frontal cortex depends on the type of fat used in the diet and correlates with neuropeptidase activities. Horm Metab Res 43:86-91, 2011.

• Atmani D, Ruiz-Larrea MB, A, Ruiz-Sanz JI, Lizcano LJ, Bakkali F, Atmani D. Antioxidant potential, cytotoxic activity and phenolic content of Clematis flammula leaf extracts. J Medicinal Plants Research 5:589-598, 2011.

• Ruiz del Agua A, Aurrekoetxea I, Elorriaga MA, Rodriguez F, Guéraud F, Ruiz-Larrea MB, Ruiz-Sanz JI. Involvement of G-463A MPO gene polymorphism in the response of post-menopausal women to hormone replacement therapy.  Menopause 18: 575-581, 2011.

• Ruiz-Sanz JI, Aurrekoetxea I, Matorras R, Ruiz-Larrea MB. The Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles. Fertil Steril 95:1601-1605, 2011.

• Lizcano LJ, Bakkali F, Ruiz-Larrea MB, Ruiz-Sanz JI. Antioxidant activity and polyphenol content of aqueous extracts from Colombian Amazonian plants with medicinal use. Food Chem 119:1566-1570, 2010.

• Aurrekoetxea I, Ruiz-Sanz JI, Ruiz del Agua A, Navarro R, Hernández ML, Matorras R, Prieto B, Ruiz-Larrea MB. Serum oxidizability and antioxidant status in patients undergoing in vitro fertilization. Fertil Steril 94:1279-1286, 2010.

• Martínez R, Navarro R, Lacort M, Ruiz-Sanz JI, Ruiz-Larrea MB. Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes. Toxicol Lett 190:86-90, 2009.

• Casós K, Sáiz MP, Ruiz-Sanz JI, Mitjavila MT. Atherosclerosis prevention by a fish oil-rich diet in apoE-/- mice is associated with a reduction of endothelial adhesion molecules.  Atherosclerosis 201:306-17, 2008.

• López D, Möller M, Denicola A, Casós K, Rubbo H, Ruiz-Sanz JI, Mitjavila MT. Long-chain n-3 PUFA from fish oil modulates aortic nitric oxide and tocopherol status in the rat. Br J Nutr 17:1-9, 2008.

• Jangi SM, Ruiz-Larrea MB, Nicolau-Galmés F, Díaz-Pérez JL, Andollo N, Arroyo-Berdugo Y, Boyano MD. Terefenadine-induced apoptosis in human melanoma cells is mediated through Ca²⁺ homoestasis modulation and tyrosine kinase activity, independently of the H1 histamine receptors. Carcinogenesis 29:500-9, 2008.

• Ruiz-Sanz JI, Navarro R, Martínez R, Hernández ML, Matorras R, Ruiz-Larrea MB. No effect of menstrual cycle on LDL oxidizability and particle size. Maturitas 57:253-260, 2007.

• Martínez R, Lacort M, Ruiz-Sanz JI, Ruiz-Larrea MB. Ferrylmyoglobin impairs secretion of VLDL triacylglycerols from stored intracellular pools: involvement of lipid peroxidation. Biochim Biophys Acta (Mol Cell Biol Lipids) 1771:590-599, 2007.

• Ruiz-Sanz JI, Aurrekoetxea I, Ruiz del Agua A, Ruiz-Larrea MB. Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR. Mol Cell Probes 21:202–207, 2007.

• Navarro R, Busnadiego I, Ruiz-Larrea MB, Ruiz-Sanz JI. Superoxide anions are involved in doxorubicin-induced ERK activation in hepatocyte cultures. Ann NY Acad Sci USA 1090:419-428, 2006.

• Navarro R, Martínez R, Busnadiego I, Ruiz-Larrea MB, Ruiz-Sanz JI. Doxorubicin-induced MAPK activation in hepatocyte cultures is independent of oxidant damage. Ann NY Acad Sci USA 1090:408-418, 2006.

• Sanjurjo P, Aldámiz-Echevarría L, Prado C, Azcona I, Elorz J, Prieto JA, Ruiz JI, Rodríguez-Soriano J. Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. Br J Nutr 95:168-73, 2006.

• García-Calatayud S, Redondo C, Martín E, Ruiz JI, García-Fuentes M, Sanjurjo P. Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. Pediatr Res 57:719-23, 2005.

• Aldámiz-Echevarría L, Vallo A, Sanjurjo P, Elorz J, Prieto JA, Ruiz JI, Rodríguez-Soriano J. Influence of diet on atherogenic risk in children with renal transplants. Pediatr Nephrol 19:1039-45, 2004.

• Aldámiz-Echevarría L, Sanjurjo P, Vallo A, Aguirre M, Pérez-Nanclares G, Gimeno P, Rueda M, Ruiz JI, Rodríguez-Soriano J. Genetic and metabolic determinants of increased plasma plasminogen activator inhibitor-1 activity in children with renal transplants. Pediatr Nephrol 18:749-55, 2003.

• Sanjurjo P, Aldamiz L, Georgi G, Jelinek J, Ruiz JI, Boehm G. Dietary threonine reduces plasma phenylalanine levels in patients with hyperphenylalaninemia. J Pediatr Gastroenterol Nutr 36:23-6, 2003.

• Ruiz-Larrea MB, Ruiz-Sanz JI. "Fitoestrógenos y salud". Antioxidants On line Journal and Antioxidants Vitamins and Nutrients (Antioxidantes Revista On line, Antioxidantes, vitaminas y nutrientes). Octubre, 2003.

• Arechaga G, Prieto I, Segarra AB, Alba F, Ruiz-Larrea MB, Ruiz-Sanz JI, de Gasparo M, Ramirez M. Dietary fatty acid composition affects aminopeptidase activities in the testes of mice. Int J Androl 25:113-8, 2002.

• Segarra AB, Arechaga G, Prieto I, Ramirez-Exposito MJ, Martinez-Martos JM, Ramirez M, Alba F, Ruiz-Larrea MB, Ruiz-Sanz JI.  Effects of dietary supplementation with fish oil, lard, or coconut oil on oxytocinase activity in the testis of mice.  Arch Androl 48:233-6, 2002.

• Martínez R, Navarro R, Martín C, Aurrekoetxea I, Hernández ML, Lacort M, Ruiz-Sanz JI, Ruiz-Larrea MB. Doxorubicin increases intracellular diacylglycerol by the mobilization of choline-enriched phospholipids in rat hepatocytes. Ann NY Acad Sci USA 973:49-51, 2002.

• Martínez R, Navarro R, Martín C, Aurrekoetxea I, Hernández ML, Lacort M, Ruiz-Sanz JI, Ruiz-Larrea MB. Intracellular diacylglycerol accumulation induced by doxorubicin in rat hepatocytes: potential involvement of phospholipases C and D. Ann NY Acad Sci USA 973:52-56, 2002.

• Martínez R, Quintana K, Navarro R, Martín C, Hernández ML, Aurrekoetxea I, Ruiz-Sanz JI, Lacort M, Ruiz-Larrea MB. Pro-oxidant and antioxidant potential of catecholestrogens against ferrylmyoglobin-induced oxidative stress. Biochim Biophys Acta (Molecular and Cell Biology of Lipids) 583:167-175, 2002.

• Aldámiz-Echevarría L, Sanjurjo P, Vallo A, Aquino L, Pérez-Nanclares G, Gimeno P, Rueda M, Ruiz I, Urreizti R, Rodríguez-Soriano J. Hyperhomocysteinemia in children with renal transplants. Pediatr Nephrol 17:718-23, 2002.

• Martín C, Martínez R, Navarro R, Ruiz-Sanz JI, Lacort M, Ruiz-Larrea MB. Tert-butyl hydroperoxide induces lipid signaling in hepatocytes: involvement of gluthatione and free radicals. Biochem Pharmacol 62:705-712, 2001.

• Ruiz-Sanz JI, Navarro R, Martínez R, Martín C, Lacort M, Matorras R, Ruiz-Larrea MB. 17ß-Estradiol affects in vivo the low density lipoprotein composition, particle size, and oxidizability. Free Radic Biol Med 31:391-397, 2001.

• Matorras R, Ruiz JI, Perteagudo L, Barbazan MJ, Diaz A, Valladolid A, Sanjurjo P. Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. J Perinat Med 29:293-7, 2001. 

• Eizaguirre I, Aldámiz L, Aldazábal P, García Urkia N, Asensio AB, Bachiller P, García Arenzana JM, Ruiz JL, Sanjurjo P, Perez Nanclares G. Tissue antioxidant capacity and bacterial translocation under total parenteral nutrition. Pediatr Surg Int 17:280-3, 2001.

• Ruiz-Larrea MB, Martín C, Martínez R, Navarro R, Lacort M, Miller NJ. Antioxidant activities of estrogens against aqueous and lipophilic radicals. differential behaviour between phenols and catechols. Chem Phys Lipids 105:179-188, 2000.