Jone Mitxelena

Jone Mitxelena

Teaching Profile

I have supervised a PhD Thesis defended in 2022, and I am currently supervising two PhD Theses. I teach in the Master's Degree in Molecular Biology and Biomedicine of the UPV/EHU. In addition, I participate in the supervision of Final Degree Projects of students of the Degrees of Biology, Biochemistry and Molecular Biology, and Biotechnology, as well as Master's Degree Projects of students of the Master in Molecular Biology and Biomedicine.

Research Profile

I performed my PhD at the University of the Basque Country (UPV/EHU) in the field of the molecular mechanisms involved in the control of cell proliferation and maintenance of genome integrity (2014). I developed my postdoctoral research in the University of Zurich (Switzerland), where I specialized in DNA damage repair mechanisms (2016-2019). In 2020, Ikerbasque Basque Foundation for Science supported my return to the UPV/EHU, where I am focused in the investigation of the transcriptional networks involved in the maintenance of genomic integrity, cell homeostasis and their involvement in tumor progression. I have been awarded the L'Oréal-UNESCO For Women in Science Award (2022), and a UPV/EHU project for junior researchers (2023).

Reasearch Project:

Chromatin Plasticity and Cancer Metastasis: Defining proinvasive states in colorectal cancer. Entidad Financiadora: UPV/EHU-PROYECTOS DE INVESTIGACIÓN LIDERADOS POR PERSONAL NOVEL.IP: Jone Mitxelena

Bases moleculares de patologías humanas de alta prevalencia: cáncer e infertilidad. Avanzando (en medicina de precisión) hacia un manejo personalizado del paciente. IT1547-22. Entidad Financiadora: Gobierno Vasco-GRUPOS CONSOLIDADOS. IP: Ana Zubiaga

Mecanismos de respuesta al daño del DNA y de progresión tumoral regidos por nuevas redes de regulación transcripcional asociadas a los factores E2F. MCIU-Proyectos de Investigación Orientada 2021 ORI. IP: Ana Zubiaga

Redes transcripcionales en la transición epitelio-mesénquima y el desarrollo de metástasis (TransEMeT). Entidad Financiadora: L'Oréal-UNESCO For Women in Science. IP: Jone Mitxelena

Publications:

1: Mitxelena J, Zubiaga AM. Foreword Special Issue Genomic Instability in Tumor

Evolution and Therapy Response. Cancers (Basel). 2023 Jun 7;15(12):3080. doi:

10.3390/cancers15123080. PMID: 37370691; PMCID: PMC10296557.

2: Hamidi M, Eriz A, Mitxelena J, Fernandez-Ares L, Aurrekoetxea I, Aspichueta

P, Iglesias-Ara A, Zubiaga AM. Targeting E2F Sensitizes Prostate Cancer Cells to

Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity. Cancers

(Basel). 2022 Oct 10;14(19):4952. doi: 10.3390/cancers14194952. PMID: 36230876;

PMCID: PMC9564059.

3: Michelena J, Pellegrino S, Spegg V, Altmeyer M. Replicated chromatin curtails

53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells. Life Sci

Alliance. 2021 Apr 2;4(6):e202101023. doi: 10.26508/lsa.202101023. PMID:

33811064; PMCID: PMC8046418.

4: Mustafa N, Mitxelena J, Infante A, Zenarruzabeitia O, Eriz A, Iglesias-Ara A,

Zubiaga AM. E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects

from Immune-Mediated Injury through Repression of Fas and FasL. Int J Mol Sci.

2021 Dec 28;23(1):311. doi: 10.3390/ijms23010311. PMID: 35008734; PMCID:

PMC8745065.

5: Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M. Basal CHK1 activity

safeguards its stability to maintain intrinsic S-phase checkpoint functions. J

Cell Biol. 2019 Sep 2;218(9):2865-2875. doi: 10.1083/jcb.201902085. Epub 2019

Jul 31. PMID: 31366665; PMCID: PMC6719454.

6: Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M. Phase

separation of 53BP1 determines liquid-like behavior of DNA repair compartments.

EMBO J. 2019 Aug 15;38(16):e101379. doi: 10.15252/embj.2018101379. Epub 2019 Jul

1. PMID: 31267591; PMCID: PMC6694294.

7: Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J,

Imhof R, Janscak P, Baubec T, Altmeyer M. Efficient Pre-mRNA Cleavage Prevents

Replication-Stress-Associated Genome Instability. Mol Cell. 2019 Feb

21;73(4):670-683.e12. doi: 10.1016/j.molcel.2018.11.036. Epub 2019 Jan 10. PMID:

30639241; PMCID: PMC6395949.

8: Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M. Analysis of

PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals

mechanisms of sensitivity and resistance. Nat Commun. 2018 Jul 11;9(1):2678.

doi: 10.1038/s41467-018-05031-9. PMID: 29992957; PMCID: PMC6041334.

9: Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo

A, Alvarez-Fernández M, Malumbres M, Zubiaga AM. An E2F7-dependent

transcriptional program modulates DNA damage repair and genomic stability.

Nucleic Acids Res. 2018 May 18;46(9):4546-4559. doi: 10.1093/nar/gky218.