Phone: 94 601 5799
Email: ainhoa.iglesias@ehu.es
Office Location: School of Science and Technology, Building F1, ground floor, office 6
Research Group: MOLECULAR BIOLOGY OF CANCER

• ORCID: 0000-0002-2056-8213
• Research ID: H-3021-2015
• Scientific Production

I began my University teaching in 2010.  Currently, I teach two subjects in the Degree in Biology: Genetics, a compulsory subject, in Basque, and Genetic Engineering and Molecular Genetic Analysis, an elective subject, in Spanish. I supervise graduate student projects in the Degree in Biology and the Degree in Biochemistry and Molecular Biology as well as master student projects within the Master in Molecular Biology and Biomedicine. In addition, during the last years, I have assumed responsibilities related to academic management, as a member of various commissions of the Faculty of Science and Technology of the UPV/EHU.

I received my doctorate in 2006 from the University of the Basque Country (UPV/EHU) with a work on the role of the Retinoblastoma/E2F pathway in the control of pancreatic and hematopoietic function. I completed my postdoctoral research activity (2006-2008) at the University of Southern California (USA), in the field of Methionine Metabolism and liver cancer, in the group led by Dr. Shelly C. Lu, with whom I continue maintaining a close collaboration. Since my reincorporation at the UPV / EHU, my research activity has been carried out in the research group led by Dr. Ana M. Zubiaga, making use of cell and animal genetic models to elucidate the role of key proteins in tumor suppression.

1: Iglesias-Ara A, Westendorp B. Editorial: The role of E2F transcription
factors in cancer. Front Oncol. 2024 Jan 4;13:1355610. doi:
10.3389/fonc.2023.1355610. PMID: 38239640; PMCID: PMC10794745.

2: Hamidi M, Eriz A, Mitxelena J, Fernandez-Ares L, Aurrekoetxea I, Aspichueta
P, Iglesias-Ara A, Zubiaga AM. Targeting E2F Sensitizes Prostate Cancer Cells to
Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity. Cancers
(Basel). 2022 Oct 10;14(19):4952. doi: 10.3390/cancers14194952. PMID: 36230876;
PMCID: PMC9564059.

3: Mustafa N, Mitxelena J, Infante A, Zenarruzabeitia O, Eriz A, Iglesias-Ara A,
Zubiaga AM. E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects
from Immune-Mediated Injury through Repression of Fas and FasL. Int J Mol Sci.
2021 Dec 28;23(1):311. doi: 10.3390/ijms23010311. PMID: 35008734; PMCID:
PMC8745065.

4: González-Romero F, Mestre D, Aurrekoetxea I, O'Rourke CJ, Andersen JB,
Woodhoo A, Tamayo-Caro M, Varela-Rey M, Palomo-Irigoyen M, Gómez-Santos B, de
Urturi DS, Núñez-García M, García-Rodríguez JL, Fernández-Ares L, Buqué X,
Iglesias-Ara A, Bernales I, De Juan VG, Delgado TC, Goikoetxea-Usandizaga N, Lee
R, Bhanot S, Delgado I, Perugorria MJ, Errazti G, Mosteiro L, Gaztambide S,
Martinez de la Piscina I, Iruzubieta P, Crespo J, Banales JM, Martínez-Chantar
ML, Castaño L, Zubiaga AM, Aspichueta P. E2F1 and E2F2-Mediated Repression of
CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment. Cancer Res. 2021 Jun
1;81(11):2874-2887. doi: 10.1158/0008-5472.CAN-20-2052. Epub 2021 Mar 26. PMID:
33771899.

5: Floris A, Mazarei M, Yang X, Robinson AE, Zhou J, Barberis A, D'hallewin G,
Azara E, Spissu Y, Iglesias-Ara A, Orrù S, Tomasi ML. SUMOylation Protects FASN
Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf
Extract. Biomolecules. 2020 Mar 31;10(4):529. doi: 10.3390/biom10040529. PMID:
32244364; PMCID: PMC7226518.

6: Peñalver-González B, Vallejo-Rodríguez J, Mentxaka G, Fullaondo A, Iglesias-
Ara A, Field SJ, Zubiaga AM. Golgi Oncoprotein <i>GOLPH3</i> Gene Expression Is
Regulated by Functional E2F and CREB/ATF Promoter Elements. Genes (Basel). 2019
Mar 25;10(3):247. doi: 10.3390/genes10030247. PMID: 30934642; PMCID: PMC6471639.

7: Iglesias-Ara A, Osinalde N, Zubiaga AM. Detection of E2F-Induced
Transcriptional Activity Using a Dual Luciferase Reporter Assay. Methods Mol
Biol. 2018;1726:153-166. doi: 10.1007/978-1-4939-7565-5_14. PMID: 29468551.

8: Tomasi ML, Ramani K, Ryoo M, Cossu C, Floris A, Murray BJ, Iglesias-Ara A,
Spissu Y, Mavila N. SUMOylation regulates cytochrome P450 2E1 expression and
activity in alcoholic liver disease. FASEB J. 2018 Jun;32(6):3278-3288. doi:
10.1096/fj.201701124R. Epub 2018 Jan 18. PMID: 29401608; PMCID: PMC5956242.