This subject delves into aspects of Cell Biology that students should know in their general aspects. Together with other subjects of the first course of dentistry complete the training of the basic subjects of these students. As far as possible, the subjects are taught taking as examples aspects related to Dentistry.

1. Autonomous learning.

2. Capacity for organization and planning.

3. Team work.

4. Information management capacity.

5. Capacity for oral and written expression.

6. Decision making.

7. Mastery of the current means of electronic communication and information technology.

8. Knowledge of scientific English in Cell Biology.

Lectures



1. Brief historical and conceptual introduction of the cell



1.1 Visualizing cells. Microscopic sizes, cellular function and differentiated cells. The cell through the history of Biology (classroom practices).



2. Cell organization



2.1 Membrane systems.



- Plasmatic membrane. Transport through the plasma membrane: diffusion and transport proteins, endocytosis and exocytosis. Intercellular signals, cellular receptors and signal transduction. Transmission of nerve signals.

- Endoplasmic reticulum, Golgi apparatus, lysosomes and vesicular traffic: composition, structure and functions.



- Energy organelles: peroxisomes and mitochondria. Composition, structure and functions.





2.3 Cytoskeleton.



-Microfilaments, intermediate filaments and microtubules.



3. Cellular contacts, cellular communication and extracellular matrix

3.1 Adhesion and cellular communication



-Intercellular junctions.



3.2 Intercellular space: extracellular matrix. Extracellular dental matrix.





4. Cell nucleus and cell life cycle



4.1 Cell nucleus: flow of genetic information, nuclear envelope, nucleus-cytoplasm transport, chromatin (structure and functions), nucleolus and ribosomes.



4.2 Cell cycle: stages, regulatory mechanisms.



4.3 Cell division: mitosis and cytokinesis. Cell death



4.4 Stem cells and cancer



Laboratory practices



- Use of the optical microscope, preparation of biological samples and most used stains (4 hours)



- Electron microscope: use and preparation of samples under the transmission and scanning electron microscope (2 hours)



 Study of cellular and extracellular components by transmission and scanning electron microscopy (6 hours)



- Study of odontogenesis: sections of cellular structures in development of the first molar and the incisor: stages of onset, morphogenesis and cell differentiation. Dentin and enamel formation (dentinogenesis and amelogenesis) (6 hours)



In the classroom practices, problems related to the topics of the subject will be made, individually or in groups, as they are explained in the lectures using the knowledge, reasoning and skills of each student.



In the seminars will be carried out classes of presentation of current topics of interest in Cell Biology and Dentistry and review of the thematic blocks presented in the theoretical classes.

The methodology is based on the master classes using the blackboard and PowerPoints on the part of the teacher where the students also participate through questions that are asked during the course of the classes.



The practical laboratory classes are developed with the use of microscopes where each student individually studies the corresponding histological preparations under the supervision of the teacher.

In the seminars, groups of 4-5 students are organized and they prepare and expose a topic of Cell Biology related to dentistry and present the work in class.

In the classroom practices, cases and problems are presented by the teacher, and solve by the students in groups of 4-5 people, and expose the solutions in public.

• Final Assessment System
• Tools and qualification percentages:
  • Written test to be taken (%): 90
  • Realization of Practical Work (exercises, cases or problems) (%): 10

ASSESSMENT SYSTEMS



• Final Evaluation System

• Tools and qualification percentages:

o Written test to develop (%): 90

o Internship (exercises, cases or problems) (%): 10



ORDINARY CALL: ORIENTATIONS AND RESIGNATION:



Partial exam with short questions (20%), practical exam (10%) and final exam with short questions (70%)



EXTRAORDINARY CALL: ORIENTATIONS AND RESIGNATION

Exam of short questions (100%)

EXTRAORDINARY CALL: ORIENTATIONS AND RESIGNATION

Exam of short questions (100%)

Basic bibliography

Cellular and molecular biology:



- In Spanish:



Alberts B. and other authors Molecular Biology of the cell. 6th ed., Editorial Omega. 2016



Alberts B. and other authors. Introduction to Cell Biology. 3rd edition. Editorial Panamericana Medical. 2011



Paniagua R. and other authors. Cell Biology 3rd edition. McGraw-Hill Interamericana. 2010



- In english:



Alberts B. and cols. Essential cell Biology. 4th edition. Garland Sciences. 2013



Alberts B. and cols. Molecular Biology of the Cell. 6th Edition. Garland Sciences Ed. 2015

Web addresses

Books
Cells II: Cellular Organization..
http://www.emc.maricopa.edu
Cell Biology Laboratory Manual
http://gac.edu/cgi-bin/user/~cellab/phpl?index-1.html
Videos:
Cells Alive! http://cellsalive.com/
PubMed:
http://www.ncbi.nim.nih.gov/PubMed/
Oral Biology practical classes:
https://courses.stu.qmul.ac.uk/smd/kb/microanatomy/oralbio/