An efficient synthesis of achiral and chiral cyclic dehydro-α-amino acid derivatives through nucleophilic addition of Amines to β,γ-unsaturated α-keto esters
- Egileak:
- Francisco Palacios, Javier Vicario, Domitila Aparicio
- Urtea:
- 2006
- Aldizkaria:
- European Journal of Organic Chemistry
- Hasierako orria - Amaierako orria:
- 2843 - 2850
- Deskribapena:
-
A very simple and efficient synthesis of 3-amino-1,5-dihydro-2H-pyrrol-2-ones is reported. These cyclic dehydro-amino acid derivatives with a stereogenic center at the 5-position were obtained by the addition of two equivalents of amine to β,γ-unsaturated keto esters. These cyclic enamines can also be obtained by the three-component reaction of ethyl pyruvate, amines and aldehydes.