Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives from Trisubstituted α-Aminophosphonates
- Egileak:
- Javier Vicario, Pablo Ortiz, Francisco Palacios
- Urtea:
- 2013
- Aldizkaria:
- European Journal Organic Chemistry
- Hasierako orria - Amaierako orria:
- 7095 - 7100
- Deskribapena:
-
An efficient method for the preparation of quaternary α-aminophosphonic acid derivatives is reported. The nucleophilic addition of organometallic reagents to α-ketiminophosphonates allows the preparation of quaternary α-aminophosphonates. The diastereoselective synthesis of a quaternary α-aminophosphonate using a chiral tartaric-acid-derived phosphonate is also described.