Publications
2023
- Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
March 2023. Luis O Romero, Rebeca Caires, A Kaitlyn Victor, Juanma Ramirez, Francisco J Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T Reiter, Valeria Vásquez, Julio F Cordero-Morales. -
P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease
February 2023. L Kumarasinghe, M A Garcia-Gimeno, J Ramirez, U Mayor, J L Zugaza, P Sanz. Neurobiol Dis.
2022
- SUMO-ID: A Strategy for the Identification of SUMO-Dependent Proximal Interactors
November 2022. Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio, James D Sutherland. Methods Mol Biol - RNAi-Based Screening for the Identification of Specific Substrate-Deubiquitinase Pairs
November 2022. Nagore Elu, Natalia Presa, Ugo Mayor. Methods Mol Biol - HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress
October 2022. Joan Sala-Gaston, Leonardo Pedrazza, Juanma Ramirez, Arturo Martinez-Martinez, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Ugo Mayor, Francesc Ventura, Jose Luis Rosa. Cell Mol Life Sci - Identification of substrates for human deubiquitinating enzymes (DUBs): An up-to-date review and a case study for neurodevelopmental disorders
January 2022. Nagore Elu, Nerea Osinalde, Juanma Ramirez, Natalia Presa, Jose Antonio Rodriguez, Gorka Prieto, Ugo Mayor. Semin Cell Dev Biol
2021
- Identification of proximal SUMO-dependent interactors using SUMO-ID
November 2022. Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M Aransay, Felix Elortza, Ugo Mayor, Alfred C O Vertegaal, Rosa Barrio, James D Sutherland. Nat Commun - Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
November 2022. Marina Serrano-Maciá, Jorge Simón, Maria J González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque , Guido A Baselli, Luca V C Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M Banales, Matias A Avila, Jose J G Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P Xirodimas, Rubén Nogueiras, Teresa C Delgado, María Luz Martínez-Chantar. Mol Metab - A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
May 2022. Juanma Ramirez, Gorka Prieto, Anne Olazabal-Herrero, Eva Borràs, Elvira Fernandez-Vigo, Unai Alduntzin, Nerea Osinalde, Javier Beaskoetxea, Benoit Lectez, Kerman Aloria, Jose Antonio Rodriguez, Alberto Paradela 9 , Eduard Sabidó, Javier Muñoz, Fernando Corrales, Jesus M Arizmendi, Ugo Mayor. Int J Mol Sci - The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF
February 2021. Juanma Ramírez, Miguel Morales, Nerea Osinalde, Imanol Martínez-Padrón, Ugo Mayor, Alberto Ferrús. Journal of Biological Chemistry
2020
- SUMOylation in the control of cholesterol homeostasis
May 2020. Ana Talamillo, Leiore Ajuria, Marco Grillo, Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio. Open Biology - The role of SUMOylation during development
April 2020. Ana Talamillo, Orhi Barroso-Gomila, Immacolata Giordano, Leiore Ajuria, Marco Grillo, Ugo Mayor, Rosa Barrio. Biochemical Society Transactions - How to Inactivate Human Ubiquitin E3 Ligases by Mutation
February 2020. Cristina Garcia-Barcena, Juanma Ramirez, Nerea Osinalde, Ugo Mayor. Frontiers in Cell and Developmental Biology
2019
- Mass Spectrometry-Based Characterization of Ub- and UbL-Modified Proteins
September 2019. Nagore Elu, Benoit Lectez, Juanma Ramirez, Nerea Osinalde, Ugo Mayor. Mass Spectrometry Data Analysis in Proteomics - Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination
May 2019. Nagore Elu, Nerea Osinalde, Javier Beaskoetxea, Juanma Ramirez, Benoit Lectez, Kerman Aloria, Jose Antonio Rodriguez, Jesus M. Arizmendi, Ugo Mayor. Frontiers in Physiology
2018
- Impaired proteostasis in rare neurological diseases
November 2018. Nerea Osinalde, Anna Duarri, Juanma Ramirez, Rosa Barrio, Guiomar Perez de Nanclares, Ugo Mayor. Seminars in Cell & Developmental Biology
- Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS during a Circadian Cycle
May 2018. Áron Szabó, Christian Papin, David Cornu, Elisabeth Chélot, Zoltán Lipinszki, Andor Udvardy, Virginie Redeker, Ugo Mayor, François Rouyer. Cell Reports - Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome
March 2018. Juanma Ramirez, Benoit Lectez, Nerea Osinalde, Monika Sivá, Nagore Elu, Kerman Aloria, Michaela Procházková, Coralia Perez, Jose Martínez-Hernández, Rosa Barrio, Klára Grantz Šašková, Jesus M Arizmendi, Ugo Mayor. Human Molecular Genetics - Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
March 2018. Juliette J. Lee, Alvaro Sanchez-Martinez, Aitor Martinez Zarate, Cristiane Benincá, Ugo Mayor, Michael J. Clague, Alexander J. Whitworth. Journal of Cell Biology - Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a
March 2018. Aitor Martinez, Juanma Ramirez, Nerea Osinalde, Jesus M. Arizmendi, Ugo Mayor. BioMed Research International - Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons
January 2018. Nora Urraca, Kevin Hope, A. Kaitlyn Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T. Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges, Lawrence T. Reiter. Molecular Autism
2017
- In Vivo Strategies to Isolate and Characterize the Neuronal Ubiquitinated Proteome
June 2017. Juanma Ramirez, Nagore Elu, Aitor Martinez, Benoit Lectez, Ugo Mayor. Neuromethods - Multi-story Parkin
May 2017.Aitor Martinez, Ugo Mayor, Michael J. Clague. Oncotarget - Quantitative proteomic analysis of Parkin substrates in Drosophila neurons
April 2017. Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor. Molecular Neurodegeneration - A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation
January 2017. Lucia Pirone, Wendy Xolalpa, Jón Otti Sigurðsson, Juanma Ramirez, Coralia Pérez, Monika González, Ainara Ruiz de Sabando, Félix Elortza, Manuel S. Rodriguez, Ugo Mayor, Jesper V. Olsen, Rosa Barrio, James D. Sutherland. Scientific Reports
2016
- Analysis of SUMOylated Proteins in Cells and In Vivo Using the bioSUMO Strategy
September 2016. Lucia Pirone, Wendy Xolalpa, Ugo Mayor, Rosa Barrio, James D. Sutherland. Methods in Molecular Biology - Isolation of Ubiquitinated Proteins to High Purity from In Vivo Samples
September 2016. Juanma Ramirez, Mingwei Min, Rosa Barrio, Catherine Lindon, Ugo Mayor. Methods in Molecular Biology
2015
- Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells
October 2015. Juanma Ramirez, Aitor Martinez, Benoit Lectez, So Young Lee, Maribel Franco, Rosa Barrio, Gunnar Dittmar, Ugo Mayor. PLoS One