PUBLICATIONS
96: Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Alfonso Martínez, Félix Elortza, César Martín, Yulia A Nevzorova, Francisco Javier Cubero, Teresa C Delgado, Rui E Castro, Jesus M Banales, Pau Sancho-Bru, Matías A Avila, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga&, María L Martínez-Chantar. Anti-miR-873-5p improves alcohol-relates iver disease by enhancing hepatic deacetylation via SIRT1. JHEP Reports 2023. DOI: https://doi.org/10.1016/j.jhepr.2023.100918
95: Asier Larrea-Sebal, Shifa Jebari-Benslaiman, Unai Galicia-Garcia, Ane San Jose-Urteaga, Kepa B. Uribe, Asier Benito-Vicente, César Martín. Predictive Modeling and Structure Analysis of Genetic Variants in Familial Hypercholesterolemia: Implications for Diagnosis and Protein Interaction Studies. Current Atherosclerosis Reports 2023. 25:839-859. DOI. 10.1007/s11883-023-01154-7.
94: Ana Gomez-Larrauri, Patricia Gangoiti, Laura Camacho, Natalia Presa, Cesar Martin, Antonio Gomez-Muñoz. Phosphatidic Acid Stimulates Lung Cancer Cell Migration through Interaction with the LPA1 Receptor and Subsequent Activation of MAP Kinases. Biomedicines 2023, 11(7), 1804; https://doi.org/10.3390/biomedicines11071804.
93: Nicolás M Suárez, Shifa Jebari-Benslaiman, Roberto Jiménez-Monzón, Asier Benito-Vicente, Yeray Brito-Casillas, Laida Garcés, Ana M González-Lleo, Antonio Tugores, Mauro Boronat, César Martin, Ana M Wägner, Rosa M Sánchez-Hernández. Age, Origin and Functional Study of the Prevalent LDLR Mutation Causing Familial Hypercholesterolaemia in Gran Canaria. Int. J. Mol. Sci. 2023, 24(14), 11319; https://doi.org/10.3390/ijms241411319.
92. Larrea-Sebal, A.; Trenti, C.; Jebari-Benslaiman, S.; Bertolini, S.; Calandra, S.; Negri, E.A.; Bonelli, E.; Benito-Vicente, A.; Uraga-Gracianteparaluceta, L.; Martin, C.; Fasano, T. Functional Characterization of p.(Arg160Gln) PCSK9 Variant Accidentally Found in a Hypercholesterolemic Subject. Int J Mol Sci 2023, 24, doi:10.3390/ijms24043330.
91. Jebari-Benslaiman, S.; Larrea-Sebal, A.; Benito-Vicente, A.; Martin, C. Cardiovascular Disease, Atherosclerosis and Familial Hypercholesterolemia: From Molecular Mechanisms Causing Pathogenicity to New Therapeutic Approaches. Int J Mol Sci 2023, 24, doi:10.3390/ijms24087659.
90. Correa, Y.; Del Giudice, R.; Waldie, S.; Thepaut, M.; Micciula, S.; Gerelli, Y.; Moulin, M.; Delaunay, C.; Fieschi, F.; Pichler, H.; Haertlein, M.; Forsyth, V.T.; Le Brun, A.; Moir, M.; Russell, R.A.; Darwish, T.; Brinck, J.; Wodaje, T.; Jansen, M.; Martin, C.; Roosen-Runge, F.; Cardenas, M. High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner. J Colloid Interface Sci 2023, 645, 627-638, doi:10.1016/j.jcis.2023.04.137.
89. Bea, A.M.; Larrea-Sebal, A.; Marco-Benedi, V.; Uribe, K.B.; Galicia-Garcia, U.; Lamiquiz-Moneo, I.; Laclaustra, M.; Moreno-Franco, B.; Fernandez-Corredoira, P.; Olmos, S.; Civeira, F.; Martin, C.; Cenarro, A. Contribution of APOE Genetic Variants to Dyslipidemia. Arterioscler Thromb Vasc Biol 2023, 43, 1066-1077, doi:10.1161/ATVBAHA.123.318977.
88. Bea, A.M.; Cenarro, A.; Marco-Bened, V.; Laclaustra, M.; Martn, C.; Ibarretxe, D.; Pint, X.; Arrobas, T.; Vials, C.; Civeira, F.; Olmos, S. Diagnosis of Familial Dysbetalipoproteinemia Based on the Lipid Abnormalities Driven by APOE2/E2 Genotype. Clin Chem 2023, 69, 140-148, doi:10.1093/clinchem/hvac213.
87. Veloso-Fernández, A.; Laza, J.M.; Ruiz-Rubio, L.; Martín, A.; Taguado, M.; Benito-Vicente, A.; Martín, C.; Vilas, J.L. Towards a new generation of non-cytotoxic shape memory thermoplastic polyurethanes for biomedical applications. Materials Today Communications 2022, doi:10.1016/j.mtcomm.2022.104730.
86. Ruiz de Gauna, M.; Biancaniello, F.; Gonzalez-Romero, F.; Rodrigues, P.M.; Lapitz, A.; Gomez-Santos, B.; Olaizola, P.; Di Matteo, S.; Aurrekoetxea, I.; Labiano, I.; Nieva-Zuluaga, A.; Benito-Vicente, A.; Perugorria, M.J.; Apodaka-Biguri, M.; Paiva, N.A.; Saenz de Urturi, D.; Buque, X.; Delgado, I.; Martin, C.; Azkargorta, M.; Elortza, F.; Calvisi, D.F.; Andersen, J.B.; Alvaro, D.; Cardinale, V.; Bujanda, L.; Banales, J.M.; Aspichueta, P. Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids. Hepatology 2022, 76, 1617-1633, doi:10.1002/hep.32344.
85. Marco-Benedi, V.; Cenarro, A.; Laclaustra, M.; Larrea-Sebal, A.; Jarauta, E.; Lamiquiz-Moneo, I.; Calmarza, P.; Bea, A.M.; Plana, N.; Pinto, X.; Martin, C.; Civeira, F. Lipoprotein(a) in hereditary hypercholesterolemia: Influence of the genetic cause, defective gene and type of mutation. Atherosclerosis 2022, 349, 211-218, doi:10.1016/j.atherosclerosis.2021.08.009.
84. Liu, K.; Zhang, Y.; Martin, C.; Ma, X.; Shen, B. Translational Bioinformatics for Human Reproductive Biology Research: Examples, Opportunities and Challenges for a Future Reproductive Medicine. Int J Mol Sci 2022, 24, doi:10.3390/ijms24010004.
83. Jebari-Benslaiman, S.; Uribe, K.B.; Benito-Vicente, A.; Galicia-Garcia, U.; Larrea-Sebal, A.; Santin, I.; Alloza, I.; Vandenbroeck, K.; Ostolaza, H.; Martin, C. Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model. Small 2022, 18, e2105915, doi:10.1002/smll.202105915.
82. Jebari-Benslaiman, S.; Galicia-Garcia, U.; Larrea-Sebal, A.; Olaetxea, J.R.; Alloza, I.; Vandenbroeck, K.; Benito-Vicente, A.; Martin, C. Pathophysiology of Atherosclerosis. Int J Mol Sci 2022, 23, doi:10.3390/ijms23063346.
81. Gonzalez-Recio, I.; Simon, J.; Goikoetxea-Usandizaga, N.; Serrano-Macia, M.; Mercado-Gomez, M.; Rodriguez-Agudo, R.; Lachiondo-Ortega, S.; Gil-Pitarch, C.; Fernandez-Rodriguez, C.; Castellana, D.; Latasa, M.U.; Abecia, L.; Anguita, J.; Delgado, T.C.; Iruzubieta, P.; Crespo, J.; Hardy, S.; Petrov, P.D.; Jover, R.; Avila, M.A.; Martin, C.; Schaeper, U.; Tremblay, M.L.; Dear, J.W.; Masson, S.; McCain, M.V.; Reeves, H.L.; Andrade, R.J.; Lucena, M.I.; Buccella, D.; Martinez-Cruz, L.A.; Martinez-Chantar, M.L. Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage. Nat Commun 2022, 13, 6816, doi:10.1038/s41467-022-34262-0.
80. Goikoetxea-Usandizaga, N.; Serrano-Macia, M.; Delgado, T.C.; Simon, J.; Fernandez Ramos, D.; Barriales, D.; Cornide, M.E.; Jimenez, M.; Perez-Redondo, M.; Lachiondo-Ortega, S.; Rodriguez-Agudo, R.; Bizkarguenaga, M.; Zalamea, J.D.; Pasco, S.T.; Caballero-Diaz, D.; Alfano, B.; Bravo, M.; Gonzalez-Recio, I.; Mercado-Gomez, M.; Gil-Pitarch, C.; Mabe, J.; Gracia-Sancho, J.; Abecia, L.; Lorenzo, O.; Martin-Sanz, P.; Abrescia, N.G.A.; Sabio, G.; Rincon, M.; Anguita, J.; Minambres, E.; Martin, C.; Berenguer, M.; Fabregat, I.; Casado, M.; Peralta, C.; Varela-Rey, M.; Martinez-Chantar, M.L. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals. Hepatology 2022, 75, 550-566, doi:10.1002/hep.32149.
79. Benito-Vicente, A.; Uribe, K.B.; Larrea-Sebal, A.; Palacios, L.; Cenarro, A.; Calle, X.; Galicia-Garcia, U.; Jebari-Benslaiman, S.; Sanchez-Hernandez, R.M.; Stef, M.; Lambert, G.; Civeira, F.; Martin, C. Leu22_Leu23 Duplication at the Signal Peptide of PCSK9 Promotes Intracellular Degradation of LDLr and Autosomal Dominant Hypercholesterolemia. Arterioscler Thromb Vasc Biol 2022, 42, e203-e216, doi:10.1161/ATVBAHA.122.315499.
78. Vado, Y.; Puras, G.; Rosique, M.; Martin, C.; Pedraz, J.L.; Jebari-Benslaiman, S.; de Pancorbo, M.M.; Zarate, J.; Perez de Nanclares, G. Design and Validation of a Process Based on Cationic Niosomes for Gene Delivery into Novel Urine-Derived Mesenchymal Stem Cells. Pharmaceutics 2021, 13, doi:10.3390/pharmaceutics13050696.
77. Uribe, K.B.; Chemello, K.; Larrea-Sebal, A.; Benito-Vicente, A.; Galicia-Garcia, U.; Bourane, S.; Jaafar, A.K.; Lambert, G.; Martin, C. A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants. Int J Mol Sci 2021, 22, doi:10.3390/ijms222413602.
76. Simon, J.; Goikoetxea-Usandizaga, N.; Serrano-Macia, M.; Fernandez-Ramos, D.; Saenz de Urturi, D.; Gruskos, J.J.; Fernandez-Tussy, P.; Lachiondo-Ortega, S.; Gonzalez-Recio, I.; Rodriguez-Agudo, R.; Gutierrez-de-Juan, V.; Rodriguez-Iruretagoyena, B.; Varela-Rey, M.; Gimenez-Mascarell, P.; Mercado-Gomez, M.; Gomez-Santos, B.; Fernandez-Rodriguez, C.; Lopitz-Otsoa, F.; Bizkarguenaga, M.; Dames, S.; Schaeper, U.; Martin, F.; Sabio, G.; Iruzubieta, P.; Crespo, J.; Aspichueta, P.; Chu, K.H.; Buccella, D.; Martin, C.; Delgado, T.C.; Martinez-Cruz, L.A.; Martinez-Chantar, M.L. Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. J Hepatol 2021, 75, 34-45, doi:10.1016/j.jhep.2021.01.043.
75. Nocedo-Mena, D.; Arrasate, S.; Garza-Gonzalez, E.; Rivas-Galindo, V.M.; Romo-Mancillas, A.; Munteanu, C.R.; Sotomayor, N.; Lete, E.; Barbolla, I.; Martin, C.A.; Del Rayo Camacho-Corona, M. Molecular docking, SAR analysis and biophysical approaches in the study of the antibacterial activity of ceramides isolated from Cissus incisa. Bioorg Chem 2021, 109, 104745, doi:10.1016/j.bioorg.2021.104745.
74. Larrea-Sebal, A.; Benito-Vicente, A.; Fernandez-Higuero, J.A.; Jebari-Benslaiman, S.; Galicia-Garcia, U.; Uribe, K.B.; Cenarro, A.; Ostolaza, H.; Civeira, F.; Arrasate, S.; Gonzalez-Diaz, H.; Martin, C. MLb-LDLr: A Machine Learning Model for Predicting the Pathogenicity of LDLr Missense Variants. JACC Basic Transl Sci 2021, 6, 815-827, doi:10.1016/j.jacbts.2021.08.009.
73. Lamiquiz-Moneo, I.; Civeira, F.; Mateo-Gallego, R.; Laclaustra, M.; Moreno-Franco, B.; Tejedor, M.T.; Palacios, L.; Martin, C.; Cenarro, A. Diagnostic yield of sequencing familial hypercholesterolemia genes in individuals with primary hypercholesterolemia. Rev Esp Cardiol (Engl Ed) 2021, 74, 664-673, doi:10.1016/j.rec.2020.06.003.
72. Uribe, K.B.; Benito-Vicente, A.; Martin, C.; Blanco-Vaca, F.; Rotllan, N. (r)HDL in theranostics: how do we apply HDL's biology for precision medicine in atherosclerosis management? Biomater Sci 2021, 9, 3185-3208, doi:10.1039/d0bm01838d.
71. Huijgen, R.; Blom, D.J.; Hartgers, M.L.; Chemello, K.; Benito-Vicente, A.; Uribe, K.B.; Behardien, Z.; Blackhurst, D.M.; Brice, B.C.; Defesche, J.C.; de Jong, A.G.; Jooste, R.J.; Solomon, G.A.E.; Wolmarans, K.H.; Hovingh, G.K.; Martin, C.; Lambert, G.; Marais, A.D. Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town. Arterioscler Thromb Vasc Biol 2021, 41, 934-943, doi:10.1161/ATVBAHA.120.314482.
70. Gracia-Rubio, I.; Martin, C.; Civeira, F.; Cenarro, A. SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies. Biomedicines 2021, 9, doi:10.3390/biomedicines9060612.
69. Gonzalez Bullon, D.; Uribe, K.B.; Amuategi, J.; Martin, C.; Ostolaza, H. Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size. FEBS J 2021, 288, 6795-6814, doi:10.1111/febs.16107.
68. Chemello, K.; Garcia-Nafria, J.; Gallo, A.; Martin, C.; Lambert, G.; Blom, D. Lipoprotein metabolism in familial hypercholesterolemia. J Lipid Res 2021, 62, 100062, doi:10.1016/j.jlr.2021.100062.
67. Alves, A.C.; Azevedo, S.; Benito-Vicente, A.; Graca, R.; Galicia-Garcia, U.; Barros, P.; Jordan, P.; Martin, C.; Bourbon, M. LDLR variants functional characterization: Contribution to variant classification. Atherosclerosis 2021, 329, 14-21, doi:10.1016/j.atherosclerosis.2021.06.001.
66. Madsen, T.D.; Hansen, L.H.; Hintze, J.; Ye, Z.; Jebari, S.; Andersen, D.B.; Joshi, H.J.; Ju, T.; Goetze, J.P.; Martin, C.; Rosenkilde, M.M.; Holst, J.J.; Kuhre, R.E.; Goth, C.K.; Vakhrushev, S.Y.; Schjoldager, K.T. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles. Nat Commun 2020, 11, 4033, doi:10.1038/s41467-020-17473-1.
65. Lamiquiz-Moneo, I.; Restrepo-Cordoba, M.A.; Mateo-Gallego, R.; Bea, A.M.; Del Pino Alberiche-Ruano, M.; Garcia-Pavia, P.; Cenarro, A.; Martin, C.; Civeira, F.; Sanchez-Hernandez, R.M. Predicted pathogenic mutations in STAP1 are not associated with clinically defined familial hypercholesterolemia. Atherosclerosis 2020, 292, 143-151, doi:10.1016/j.atherosclerosis.2019.11.025.
64. Jebari-Benslaiman, S.; Uribe, K.B.; Benito-Vicente, A.; Galicia-Garcia, U.; Larrea-Sebal, A.; Alloza, I.; Vandenbroeck, K.; Ostolaza, H.; Martin, C. Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition. Biomedicines 2020, 8, doi:10.3390/biomedicines8100373.
63. Gomez-Santos, B.; Saenz de Urturi, D.; Nunez-Garcia, M.; Gonzalez-Romero, F.; Buque, X.; Aurrekoetxea, I.; Gutierrez de Juan, V.; Gonzalez-Rellan, M.J.; Garcia-Monzon, C.; Gonzalez-Rodriguez, A.; Mosteiro, L.; Errazti, G.; Mifsut, P.; Gaztambide, S.; Castano, L.; Martin, C.; Nogueiras, R.; Martinez-Chantar, M.L.; Syn, W.K.; Aspichueta, P. Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. Aging Cell 2020, 19, e13183, doi:10.1111/acel.13183.
62. Galicia-Garcia, U.; Jebari, S.; Larrea-Sebal, A.; Uribe, K.B.; Siddiqi, H.; Ostolaza, H.; Benito-Vicente, A.; Martin, C. Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights. Int J Mol Sci 2020, 21, doi:10.3390/ijms21134725.
61. Galicia-Garcia, U.; Benito-Vicente, A.; Uribe, K.B.; Jebari, S.; Larrea-Sebal, A.; Alonso-Estrada, R.; Aguilo-Arce, J.; Ostolaza, H.; Palacios, L.; Martin, C. Mutation type classification and pathogenicity assignment of sixteen missense variants located in the EGF-precursor homology domain of the LDLR. Sci Rep 2020, 10, 1727, doi:10.1038/s41598-020-58734-9.
60. Galicia-Garcia, U.; Benito-Vicente, A.; Jebari, S.; Larrea-Sebal, A.; Siddiqi, H.; Uribe, K.B.; Ostolaza, H.; Martin, C. Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci 2020, 21, doi:10.3390/ijms21176275.
59. Etxaniz, A.; Gonzalez-Bullon, D.; Martin, C.; Alonso, M.T.; Ostolaza, H. Irreversible versus repairable membrane poration: differences in permeabilization elicited by Bordetella Adenylate Cyclase Toxin and its hemolysin domain in macrophages. FEBS J 2020, 287, 1798-1815, doi:10.1111/febs.15106.
58. Benito-Vicente, A.; Uribe, K.B.; Rotllan, N.; Ramirez, C.M.; Jebari-Benslaiman, S.; Goedeke, L.; Canfran-Duque, A.; Galicia-Garcia, U.; Saenz De Urturi, D.; Aspichueta, P.; Suarez, Y.; Fernandez-Hernando, C.; Martin, C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. Int J Mol Sci 2020, 21, doi:10.3390/ijms21228675.
57. Alloza, I.; Salegi, A.; Mena, J.; Navarro, R.T.; Martin, C.; Aspichueta, P.; Salazar, L.M.; Carpio, J.U.; Cagigal, P.D.; Vega, R.; Trivino, J.C.; Freijo, M.D.M.; Vandenbroeck, K. BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque. Int J Mol Sci 2020, 21, doi:10.3390/ijms21249387.
56. Zubiete-Franco, I.; Garcia-Rodriguez, J.L.; Lopitz-Otsoa, F.; Serrano-Macia, M.; Simon, J.; Fernandez-Tussy, P.; Barbier-Torres, L.; Fernandez-Ramos, D.; Gutierrez-de-Juan, V.; Lopez de Davalillo, S.; Carlevaris, O.; Beguiristain Gomez, A.; Villa, E.; Calvisi, D.; Martin, C.; Berra, E.; Aspichueta, P.; Beraza, N.; Varela-Rey, M.; Avila, M.; Rodriguez, M.S.; Mato, J.M.; Diaz-Moreno, I.; Diaz-Quintana, A.; Delgado, T.C.; Martinez-Chantar, M.L. SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer. EBioMedicine 2019, 40, 406-421, doi:10.1016/j.ebiom.2018.12.031.
55. Wang, S.; Mao, Y.; Narimatsu, Y.; Ye, Z.; Tian, W.; Goth, C.K.; Lira-Navarrete, E.; Pedersen, N.B.; Benito-Vicente, A.; Martin, C.; Uribe, K.B.; Hurtado-Guerrero, R.; Christoffersen, C.; Seidah, N.G.; Nielsen, R.; Christensen, E.I.; Hansen, L.; Bennett, E.P.; Vakhrushev, S.Y.; Schjoldager, K.T.; Clausen, H. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. J Biol Chem 2019, 294, 8349, doi:10.1074/jbc.AAC119.009121.
54. Sanchez-Hernandez, R.M.; Di Taranto, M.D.; Benito-Vicente, A.; Uribe, K.B.; Lamiquiz-Moneo, I.; Larrea-Sebal, A.; Jebari, S.; Galicia-Garcia, U.; Novoa, F.J.; Boronat, M.; Wagner, A.M.; Civeira, F.; Martin, C.; Fortunato, G. The Arg499His gain-of-function mutation in the C-terminal domain of PCSK9. Atherosclerosis 2019, 289, 162-172, doi:10.1016/j.atherosclerosis.2019.08.020.
53. Ostolaza, H.; Gonzalez-Bullon, D.; Uribe, K.B.; Martin, C.; Amuategi, J.; Fernandez-Martinez, X. Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form? Toxins (Basel) 2019, 11, doi:10.3390/toxins11060354.
52. Gonzalez-Bullon, D.; Uribe, K.B.; Largo, E.; Guembelzu, G.; Garcia-Arribas, A.B.; Martin, C.; Ostolaza, H. Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size. Biomolecules 2019, 9, doi:10.3390/biom9050183.
51. Chemello, K.; Martin, C.; Lambert, G. PCSK9 inhibition for autosomal recessive hypercholesterolemia. Atherosclerosis 2019, 284, 209-211, doi:10.1016/j.atherosclerosis.2019.02.013.
50. Bea, A.M.; Lamiquiz-Moneo, I.; Marco-Benedi, V.; Mateo-Gallego, R.; Perez-Calahorra, S.; Jarauta, E.; Martin, C.; Cenarro, A.; Civeira, F. Lipid-lowering response in subjects with the p.(Leu167del) mutation in the APOE gene. Atherosclerosis 2019, 282, 143-147, doi:10.1016/j.atherosclerosis.2019.01.024.
49. Banerjee, P.; Chan, K.C.; Tarabocchia, M.; Benito-Vicente, A.; Alves, A.C.; Uribe, K.B.; Bourbon, M.; Skiba, P.J.; Pordy, R.; Gipe, D.A.; Gaudet, D.; Martin, C. Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity. Arterioscler Thromb Vasc Biol 2019, 39, 2248-2260, doi:10.1161/ATVBAHA.119.313051.
48. Wang, S.; Mao, Y.; Narimatsu, Y.; Ye, Z.; Tian, W.; Goth, C.K.; Lira-Navarrete, E.; Pedersen, N.B.; Benito-Vicente, A.; Martin, C.; Uribe, K.B.; Hurtado-Guerrero, R.; Christoffersen, C.; Seidah, N.G.; Nielsen, R.; Christensen, E.I.; Hansen, L.; Bennett, E.P.; Vakhrushev, S.Y.; Schjoldager, K.T.; Clausen, H. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. J Biol Chem 2018, 293, 7408-7422, doi:10.1074/jbc.M117.817981.
47. Gonzalez-Bullon, D.; Martin, C.; Ostolaza, H. Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin. Toxins (Basel) 2018, 10, doi:10.3390/toxins10120514.
46. Etxaniz, A.; Gonzalez-Bullon, D.; Martin, C.; Ostolaza, H. Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins. Toxins (Basel) 2018, 10, doi:10.3390/toxins10060234.
45. Benito-Vicente, A.; Uribe, K.B.; Siddiqi, H.; Jebari, S.; Galicia-Garcia, U.; Larrea-Sebal, A.; Cenarro, A.; Stef, M.; Ostolaza, H.; Civeira, F.; Palacios, L.; Martin, C. Replacement of cysteine at position 46 in the first cysteine-rich repeat of the LDL receptor impairs apolipoprotein recognition. PLoS One 2018, 13, e0204771, doi:10.1371/journal.pone.0204771.
44. Benito-Vicente, A.; Uribe, K.B.; Jebari, S.; Galicia-Garcia, U.; Ostolaza, H.; Martin, C. Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants. Int J Mol Sci 2018, 19, doi:10.3390/ijms19061676.
43. Benito-Vicente, A.; Uribe, K.B.; Jebari, S.; Galicia-Garcia, U.; Ostolaza, H.; Martin, C. Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease. Int J Mol Sci 2018, 19, doi:10.3390/ijms19113426.
42. Benito-Vicente, A.; Siddiqi, H.; Uribe, K.B.; Jebari, S.; Galicia-Garcia, U.; Larrea-Sebal, A.; Stef, M.; Ostolaza, H.; Palacios, L.; Martin, C. p.(Asp47Asn) and p.(Thr62Met): non deleterious LDL receptor missense variants functionally characterized in vitro. Sci Rep 2018, 8, 16614, doi:10.1038/s41598-018-34715-x.
41. Alves, A.C.; Benito-Vicente, A.; Medeiros, A.M.; Reeves, K.; Martin, C.; Bourbon, M. Further evidence of novel APOB mutations as a cause of familial hypercholesterolaemia. Atherosclerosis 2018, 277, 448-456, doi:10.1016/j.atherosclerosis.2018.06.819.
40. Ahyayauch, H.; Garcia-Arribas, A.B.; Sot, J.; Gonzalez-Ramirez, E.J.; Busto, J.V.; Monasterio, B.G.; Jimenez-Rojo, N.; Contreras, F.X.; Rendon-Ramirez, A.; Martin, C.; Alonso, A.; Goni, F.M. Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells. Sci Rep 2018, 8, 7456, doi:10.1038/s41598-018-25905-8.
39. Ugarte-Uribe, B.; Grijalvo, S.; Pertinez, S.N.; Busto, J.V.; Martin, C.; Alagia, A.; Goni, F.M.; Eritja, R.; Alkorta, I. Lipid-modified oligonucleotide conjugates: Insights into gene silencing, interaction with model membranes and cellular uptake mechanisms. Bioorg Med Chem 2017, 25, 175-186, doi:10.1016/j.bmc.2016.10.024.
38. Ostolaza, H.; Martin, C.; Gonzalez-Bullon, D.; Uribe, K.B.; Etxaniz, A. Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes. Toxins (Basel) 2017, 9, doi:10.3390/toxins9100295.
37. Jiang, L.; Benito-Vicente, A.; Tang, L.; Etxebarria, A.; Cui, W.; Uribe, K.B.; Pan, X.D.; Ostolaza, H.; Yang, S.W.; Zhou, Y.J.; Martin, C.; Wang, L.Y. Analysis of LDLR variants from homozygous FH patients carrying multiple mutations in the LDLR gene. Atherosclerosis 2017, 263, 163-170, doi:10.1016/j.atherosclerosis.2017.06.014.
36. Gonzalez-Bullon, D.; Uribe, K.B.; Martin, C.; Ostolaza, H. Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain. Proc Natl Acad Sci U S A 2017, 114, E6784-E6793, doi:10.1073/pnas.1701783114.
35. Di Taranto, M.D.; Benito-Vicente, A.; Giacobbe, C.; Uribe, K.B.; Rubba, P.; Etxebarria, A.; Guardamagna, O.; Gentile, M.; Martin, C.; Fortunato, G. Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia. Sci Rep 2017, 7, 15282, doi:10.1038/s41598-017-15543-x.
34. Jiang, L.; Wu, W.F.; Sun, L.Y.; Chen, P.P.; Wang, W.; Benito-Vicente, A.; Zhang, F.; Pan, X.D.; Cui, W.; Yang, S.W.; Zhou, Y.J.; Martin, C.; Wang, L.Y. The use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia. Sci Rep 2016, 6, 36823, doi:10.1038/srep36823.
33. Fernandez-Higuero, J.A.; Benito-Vicente, A.; Etxebarria, A.; Milicua, J.C.; Ostolaza, H.; Arrondo, J.L.; Martin, C. Structural changes induced by acidic pH in human apolipoprotein B-100. Sci Rep 2016, 6, 36324, doi:10.1038/srep36324.
32. Cenarro, A.; Etxebarria, A.; de Castro-Oros, I.; Stef, M.; Bea, A.M.; Palacios, L.; Mateo-Gallego, R.; Benito-Vicente, A.; Ostolaza, H.; Tejedor, T.; Martin, C.; Civeira, F. The p.Leu167del Mutation in APOE Gene Causes Autosomal Dominant Hypercholesterolemia by Down-regulation of LDL Receptor Expression in Hepatocytes. J Clin Endocrinol Metab 2016, 101, 2113-2121, doi:10.1210/jc.2015-3874.
31. Alonso, R.; Mata, P.; Muniz, O.; Fuentes-Jimenez, F.; Diaz, J.L.; Zambon, D.; Tomas, M.; Martin, C.; Moyon, T.; Croyal, M.; Thedrez, A.; Lambert, G. PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia. Atherosclerosis 2016, 254, 249-253, doi:10.1016/j.atherosclerosis.2016.08.038.
30. Martin, C.; Etxaniz, A.; Uribe, K.B.; Etxebarria, A.; Gonzalez-Bullon, D.; Arlucea, J.; Goni, F.M.; Arechaga, J.; Ostolaza, H. Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells. Sci Rep 2015, 5, 13774, doi:10.1038/srep13774.
29. Fernandez-Higuero, J.A.; Etxebarria, A.; Benito-Vicente, A.; Alves, A.C.; Arrondo, J.L.; Ostolaza, H.; Bourbon, M.; Martin, C. Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity. Sci Rep 2015, 5, 18184, doi:10.1038/srep18184.
28. Etxebarria, A.; Benito-Vicente, A.; Stef, M.; Ostolaza, H.; Palacios, L.; Martin, C. Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats. Atherosclerosis 2015, 238, 304-312, doi:10.1016/j.atherosclerosis.2014.12.026.
27. Etxebarria, A.; Benito-Vicente, A.; Palacios, L.; Stef, M.; Cenarro, A.; Civeira, F.; Ostolaza, H.; Martin, C. Functional characterization and classification of frequent low-density lipoprotein receptor variants. Hum Mutat 2015, 36, 129-141, doi:10.1002/humu.22721.
26. Benito-Vicente, A.; Alves, A.C.; Etxebarria, A.; Medeiros, A.M.; Martin, C.; Bourbon, M. The importance of an integrated analysis of clinical, molecular, and functional data for the genetic diagnosis of familial hypercholesterolemia. Genet Med 2015, 17, 980-988, doi:10.1038/gim.2015.14.
25. Alves, A.C.; Etxebarria, A.; Medeiros, A.M.; Benito-Vicente, A.; Thedrez, A.; Passard, M.; Croyal, M.; Martin, C.; Lambert, G.; Bourbon, M. Characterization of the first PCSK9 gain of function homozygote. J Am Coll Cardiol 2015, 66, 2152-2154, doi:10.1016/j.jacc.2015.08.871.
24. Fernandez-Higuero, J.A.; Salvador, A.M.; Martin, C.; Milicua, J.C.; Arrondo, J.L. Human LDL structural diversity studied by IR spectroscopy. PLoS One 2014, 9, e92426, doi:10.1371/journal.pone.0092426.
23. Etxebarria, A.; Benito-Vicente, A.; Alves, A.C.; Ostolaza, H.; Bourbon, M.; Martin, C. Advantages and versatility of fluorescence-based methodology to characterize the functionality of LDLR and class mutation assignment. PLoS One 2014, 9, e112677, doi:10.1371/journal.pone.0112677.
22. Alves, A.C.; Etxebarria, A.; Soutar, A.K.; Martin, C.; Bourbon, M. Novel functional APOB mutations outside LDL-binding region causing familial hypercholesterolaemia. Hum Mol Genet 2014, 23, 1817-1828, doi:10.1093/hmg/ddt573.
21. Uribe, K.B.; Martin, C.; Etxebarria, A.; Gonzalez-Bullon, D.; Gomez-Bilbao, G.; Ostolaza, H. Ca2+ influx and tyrosine kinases trigger Bordetella adenylate cyclase toxin (ACT) endocytosis. Cell physiology and expression of the CD11b/CD18 integrin major determinants of the entry route. PLoS One 2013, 8, e74248, doi:10.1371/journal.pone.0074248.
20. Uribe, K.B.; Etxebarria, A.; Martin, C.; Ostolaza, H. Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain. PLoS One 2013, 8, e67648, doi:10.1371/journal.pone.0067648.
19. Ugarte-Uribe, B.; Grijalvo, S.; Busto, J.V.; Martin, C.; Eritja, R.; Goni, F.M.; Alkorta, I. Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells. Biochim Biophys Acta 2013, 1830, 4872-4884, doi:10.1016/j.bbagen.2013.06.013.
18. Etxebarria, A.; Palacios, L.; Stef, M.; Tejedor, D.; Uribe, K.B.; Oleaga, A.; Irigoyen, L.; Torres, B.; Ostolaza, H.; Martin, C. Functional characterization of splicing and ligand-binding domain variants in the LDL receptor. Hum Mutat 2012, 33, 232-243, doi:10.1002/humu.21630.
17. Zazo, C.; Thiele, S.; Martin, C.; Fernandez-Rebollo, E.; Martinez-Indart, L.; Werner, R.; Garin, I.; Spanish, P.H.P.G.; Hiort, O.; Perez de Nanclares, G. Gsalpha activity is reduced in erythrocyte membranes of patients with psedohypoparathyroidism due to epigenetic alterations at the GNAS locus. J Bone Miner Res 2011, 26, 1864-1870, doi:10.1002/jbmr.369.
16. Martin, C.; Uribe, K.B.; Gomez-Bilbao, G.; Ostolaza, H. Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity. PLoS One 2011, 6, e17383, doi:10.1371/journal.pone.0017383.
15. Martin, C.; Gomez-Bilbao, G.; Ostolaza, H. Bordetella adenylate cyclase toxin promotes calcium entry into both CD11b+ and CD11b- cells through cAMP-dependent L-type-like calcium channels. J Biol Chem 2010, 285, 357-364, doi:10.1074/jbc.M109.003491.
14. Martin, C.; Requero, M.A.; Masin, J.; Konopasek, I.; Goni, F.M.; Sebo, P.; Ostolaza, H. Membrane restructuring by Bordetella pertussis adenylate cyclase toxin, a member of the RTX toxin family. J Bacteriol 2004, 186, 3760-3765, doi:10.1128/JB.186.12.3760-3765.2004.
13. Martinez, R.; Quintana, K.; Navarro, R.; Martin, C.; Hernandez, M.L.; Aurrekoetxea, I.; Ruiz-Sanz, J.I.; Lacort, M.; Ruiz-Larrea, M.B. Pro-oxidant and antioxidant potential of catecholestrogens against ferrylmyoglobin-induced oxidative stress. Biochim Biophys Acta 2002, 1583, 167-175, doi:10.1016/s1388-1981(02)00207-x.
12. Martinez, R.; Navarro, R.; Martin, C.; Aurrekoetxea, I.; Hernandez, M.L.; Lacort, M.; Ruiz-Sanz, J.I.; Ruiz-Larrea, M.B. Doxorubicin increases intracellular diacylglycerol by the mobilization of choline-enriched phospholipids in rat hepatocytes. Ann N Y Acad Sci 2002, 973, 49-51, doi:10.1111/j.1749-6632.2002.tb04604.x.
11. Martinez, R.; Navarro, R.; Martin, C.; Aurrekoetxea, I.; Hernandez, M.L.; Lacort, M.; Ruiz-Sanz, J.I.; Ruiz-Larrea, M.B. Intracellular diacylglycerol accumulation induced by doxorubicin in rat hepatocytes: potential involvement of phospholipases C and D. Ann N Y Acad Sci 2002, 973, 52-56, doi:10.1111/j.1749-6632.2002.tb04605.x.
10. Ruiz-Sanz, J.I.; Navarro, R.; Martinez, R.; Martin, C.; Lacort, M.; Matorras, R.; Ruiz-Larrea, M.B. 17beta-estradiol affects in vivo the low density lipoprotein composition, particle size, and oxidizability. Free Radic Biol Med 2001, 31, 391-397, doi:10.1016/s0891-5849(01)00596-2.
9. Martin, C.; Martinez, R.; Navarro, R.; Ruiz-Sanz, J.I.; Lacort, M.; Ruiz-Larrea, M.B. tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals. Biochem Pharmacol 2001, 62, 705-712, doi:10.1016/s0006-2952(01)00704-3.
8. Ruiz-Larrea, M.B.; Martin, C.; Martinez, R.; Navarro, R.; Lacort, M.; Miller, N.J. Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catechol estrogens. Chem Phys Lipids 2000, 105, 179-188, doi:10.1016/s0009-3084(00)00120-1.
7. Ruiz-Larrea, M.B.; Martin, C.; Babenko, N.A.; Martinez, R.; Lacort, M. Diethylstilbestrol antagonizes the oxidant-induced transformations of membrane phospholipids. Biochem Soc Trans 1998, 26, S224, doi:10.1042/bst026s224.
6. Martin, C.; Barturen, K.; Martinez, R.; Lacort, M.; Ruiz-Larrea, M.B. In vitro inhibition by estrogens of the oxidative modifications of human lipoproteins. J Physiol Biochem 1998, 54, 195-202.
5. Babenko, N.A.; Ruiz-Larrea, M.B.; Martinez, R.; Martin, C.; Lacort, M. Inhibition by estrogens of the oxidant-mediated mobilization of arachidonic acid in hepatocytes. J Physiol Biochem 1998, 54, 77-84.
4. Ruiz-Larrea, M.B.; Leal, A.M.; Martin, C.; Martinez, R.; Lacort, M. Antioxidant action of estrogens in rat hepatocytes. Rev Esp Fisiol 1997, 53, 225-229.
3. Ruiz-Larrea, M.B.; Leal, A.; Martinez, R.; Martin, C.; Lacort, M. Mechanism of inhibition of microsomal lipid peroxidation by estrogens: possible interactions with the cytochrome P450-dependent monooxygenase system. Biochem Soc Trans 1995, 23, 256S, doi:10.1042/bst023256s.
2. Ruiz-Larrea, B.; Leal, A.; Martin, C.; Martinez, R.; Lacort, M. Effects of estrogens on the redox chemistry of iron: a possible mechanism of the antioxidant action of estrogens. Steroids 1995, 60, 780-783, doi:10.1016/0039-128x(95)00119-b.
Lacort, M.; Leal, A.M.; Liza, M.; Martin, C.; Martinez, R.; Ruiz-Larrea, M.B. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids 1995, 30, 141-146, doi:10.1007/BF02538267.