BASIC AND GENERAL COMPETENCES



GENERAL:

G007 – To develop ethical commitment, motivation for quality and the ability to participate in social debate, showing sensitivity towards environmental and social issues.



BASIC:

CB2 - Students know how to apply their knowledge to their work or vocation in a professional manner and possess the competences that are usually demonstrated through the elaboration and defence of arguments and the resolution of problems within their area of study.

CB4 - Students are able to communicate information, ideas, problems and solutions to both specialist and non-specialist audiences.

CB5 - Students have developed those learning skills necessary to undertake further studies with a high degree of autonomy.





SPECIFIC COMPETENCES

1- To know how to carry out the necessary steps to conduct a production process mediated by microorganisms at different scales of production, from laboratory to industrial scale.

2- To know the biotechnological processes carried out by microorganisms in the different thematic fields, food, health, environment, and their relationship with industry and society.

3- To apply the knowledge to practical production of different biotechnological products.



LEARNING OUTCOMES

1- Students understand the role of the different compounds of growth and production media.

2- Students are able to design a process for the production and recovery of a biotechnological product.

3- Students know the main microorganisms involved in biotechnological processes.

4- Students understand the main biotechnological processes and their possibilities of improvement.

THEORETICAL PROGRAMME

1. Development of a microbial biotechnology process. Stages of a production process.

2. Design of culture media in industry.

3. Development of inoculum in industrial processes.

4. Sterilisation.

5. Installations and equipment. Types of bioreactors and their operation.

6. Product recovery.

7. Microbial biotechnological processes in the food industry. Products of lactic fermentation, alcoholic fermentation, acetogenesis, food additives, and single cell protein.

8. Organic solvents. Biofuels.



PRACTICAL PROGRAMME

1. Winemaking

2. Antibiotic production.

3. Antibiotic sensitivity testing. Antibiogram.



9. Microbial biotechnological processes for obtaining primary metabolites.

10. Microbial biotechnological processes in the pharmaceutical industry. Production of antibiotics, steroids, therapeutic proteins, vaccines and hormones.

11. Other microbial biotechnological processes. Biomining, Biotransformations, Bioremediation.

Theoretical lectures will be combined with laboratory practice.

Seminars will be held in which an industrial process will be studied and improvements will be proposed in group work.

Visits will be made to companies of the sector.

CONTINUOUS ASSESSMENT

1) Written exam with essay questions. The correctness and elaboration of the answers will be assessed. 50% of the final grade.

2) Laboratory and field practice. Compulsory attendance and written exam. Continuous and exam evaluation. 30% of the final grade.

3) Seminars. Active participation and the performance and presentation of team work will be assessed. 20% of the final grade.



It will be necessary to pass each of the sections separately (with a 5 out of 10) in order to pass the course. The completion of laboratory and field practice will be compulsory.



FINAL ASSESSMENT

Students will have the right to be assessed by means of the final assessment system. To do so, they must submit a written waiver of continuous assessment to the lecturer responsible for the subject within a maximum period of 9 weeks from the beginning of the semester, in accordance with the academic calendar of the centre. In this case, the student will prove the attainment of knowledge and competences inherent to the subject through a single final test (written exam) which will comprise 100% of the final grade of the subject.



During the written exams, the use by students of books or notes, as well as telephone, electronic, computer or any other type of apparatus or device, is forbidden. [Only the use of a calculator* is permitted.] In the event of any case of dishonest or fraudulent practice, the provisions of the protocol on academic ethics and prevention of dishonest or fraudulent practices in assessment tests and academic work at the UPV/EHU will be applied.



WITHDRAWAL FROM THE EXAM

Failure to assist to the exams on the official exam date will mean the automatical withdrawal of the student from the exam. In this case, the final grade will be no-presented.

Lab coat, practice protocol, and permanent marker pen.

Basic bibliography

- Okafor N., Okeke BC (2018) Modern industrial microbiology and biotechnology. 2nd edition. Science Publishers.

- Waites MJ, NL Morgan, JS Rockey, G Hington. (2001) Industrial Microbiology. An Introduction. Blackwell Science, Oxford.

- Thieman J, Palladino MA, (2010). Introducción a la Biotecnología. 2º edición. Pearson.

- Madigan MT (2015). Brock, Biología de los microorganismos. 14a edición. Pearson Educación.

- Baltz RH ,Demain AL, Davies JE. (2010). Manual of industrial Microbiology and Biotechnology. 3rd edition. ASM Press.

- Lee Y (2013) Microbial biotechnology: principles and applications. 3rd edition. Word Scientific Pub.

- Leveau JY, M Bouix. (2000) Microbiología industrial: Los microorganismos de interés industrial. Acribia. Zaragoza.

- Ratledge C, Kristiansen B. (2006) Basic Biotechnology. 3rd edition. Cambridge Univ. Press.

- Renneberg R (2019). Biotecnología para principiantes (electrónico). Editorial Reverte.

- Satyanarayana T, Kunze G. (2009). Yeast Biotechnology: diversity and applications. Springer.

In-depth bibliography

- Baglio E. (2014) Chemistry and Technology of Yoghurt Fermentation. Springer.
- Bamforth CW. (2006) Brewing: New technologies. Woodhead, Cambridge.
- Briggs DE, Boulton CA, Brookes PA, Stevens R. (2004) Brewing: Science and Practice. Woodhead Publishing
- Eibl D, Eibl E(2014) Disposable Bioreactors II. Springer.
- El-Mansi EMT, Mielsen J, Mousdale D, Allman T, Carlson R. (2019) Fermentation microbiology and biotechnology. 4th edition. Taylor and Francis.
- Glick BR, Patten CL. (2022). Molecular Biotechnology: Principles and Applications of Recombinant DNA. 6th edition. ASP Press
- Hui YH, Goddik LM, Hansen AS, Josephsen J, Nip WK.(2004) Handbook of food and beverage fermentation technology. Marcel Dekker.
- Pires E, Brányik T. (2015). Biochemistry of Beer Fermentation. Springer.
- Scragg A (2005) Environmental Microbiology (2nd ed.) Oxford University Press.
- Singh Jr. VP, Stapleton RD.(2002). Biotransformations: Bioremediation Technology for Health and Environmental Protection. Elsevier Science Ltd.
- Spencer JFT, Ragout de Spencer AL. (2001). Food Microbiology Protocols. Humana Press.
- Tkacz JS, Lange L (2004) Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine. Springer.

Journals

Biotechnology Advances
Biotechnology Annual Review
Critical Reviews in Biotechnology
Current Opinion in Biotechnology
Journal of Biotechnology
Microbial Biotechnology
Microbiology today
Nature Biotechnology
The scientist
Trends in Biotechnology