DESCRIPTION AND CONTEXTUALIZATION OF THE SUBJECT



As it is a new area of a multidisciplinary nature, this subject is related to other general (and prior) subject of the Undergraduate Degree Course in Chemistry and Physics and some from Biology (Genetics, Cellular Biology). Knowledge will be acquired on an area that is considered a priority and with great future potential, both in terms of development and for its economic potential. This knowledge can be applied to, among others, the academic, hospital, pharmaceutical and food sectors.

COMPETENCIES / LEARNING OUTCOMES OF THE SUBJECT



General and cross-cutting skills:

Learn the basis of the experimental strategies used in biochemical research.

List the molecular knowledge acquired with possible biomedical applications.

Interpret and evaluate the scientific literature on the area.

Transmit ideas and communicate them to a professional and non-professional audience, fostering the use of foreign languages, particularly English.



Specific competencies/Learning outcomes

The ability to recognize technological advances and current problems in the mastery of nanotechnology as a multidisciplinary science.

The ability to apply microscope techniques to characterization on a nanoscale.

The ability to handle the basic tools of nanomanufacturing and nanomanipulation.

Obtain a general vision of the applications of nanotechnology in the fields of cellular and molecular biology and biomedicine and understand the exceptional advantages that this science offers in comparison with conventional biological study techniques.

Develop basic experimental skills related to the application of nanometric techniques in biotechnology and biomedicine.

THEORETICAL-PRACTICAL CONTENT



Introduction to nanotechnology. The interface between nanotechnology and biotechnology.

Properties on the nano scale. Need for the nano scale and its characteristics: Nanoelectronics, nanomagnetism and nanophotonics.



Nanotools I: Instrumental techniques for characterization. Microscopes: AFM, electronic, NSOM. Other techniques (SPR....).



Nanotools II: Nanomanufacturing strategies and techniques. Types of nanolithography and Nano modeling. Nanomanipulation.



Nanomaterials and nanoparticles: Based on carbon, of natural original, metallic.

Principles of self-organization of biological macromolecules and their use in nanoengineering. Uses.



Microfluids: Behavior of fluids on the microscale and subjected to fields. Applications. Lab on chip. Nano biosensors.



Applications in Biology: Microstamping of molecules and cells. Artificial intelligence (Deep learning). DNA origami. Sequencing of DNA with nanopores. Use of nanopores for analytical purposes. Cell cultures: Nano matrixes in 2 and 3 dimensions. (Nanofibers).



Applications to Biomedicine Nano systems for diagnosis and treatment. Controlled release of medical drugs. Regenerative nanomedicine. Other medical applications: Implants and surgery.



Economic and social impact. Current legislation. Future prospects and risk assessment.

METHODOLOGY



In lectures, the contents will be explained, and exercises and problems related to the concepts explained with the worked on. Practical computer classes will consist of sessions in which simulations of the use of complex techniques will be carried out, such as Atomic Force Microscopy (AFM). In the seminars the students will present, individually or in groups, current issues, and in the field visits a nanoscience research center will be visited.

• Final Assessment System
• Tools and qualification percentages:
  • Written test to be taken (%): 60
  • Realization of Practical Work (exercises, cases or problems) (%): 22
  • Individual works (%): 12
  • Report about the visit to Nanotechnology centers (%): 6

ORDINARY CALL: GUIDANCE AND WITHDRAWAL



The subject will be assessed taking the following factors into account:

1) Taking an exam that may include short, multiple-choice-type questions and problem solving. This part will represent 60% of the final grade.

2) Assessment of classwork and an individual or seminar project. The level of active participation in class discussions will also be taken into account (12%)

3) Assessment of the field visit to research centers in NanoSciences, and report on the visit (6%)

4) Assessment of the work associated with practical computer tasks (10%)

5) Assessment of laboratory practical work (12%).

Extraordinary call: GUIDANCE



If the subject is not approved in the ordinary call, the partial grades of the approved sections will be saved for the extraordinary call of the current year (July). The assessment criteria are the same as in the ordinary call.

MANDATORY USE MATERIALS

- Egela course available at the beginning of the term
- Additional material (articles, reviews etc) provided on the lectures

Basic bibliography

- Bionanotechnology.Concepts and Applications. Ljiljana Fruk & Antonina Kerbs.Cambridge University

Press, 2021.

- Nanotechnology: An Introduction (2nd edition).Jeremy J. Ramsden.Elsevier, 2016.

- Introduction to BioMEMS. Albert Folch, CRC Press, 2012.

- NANOTECHNOLOG IN BIOLOGY AND MEDICINE: Methods, Devices, and Applications. Tuan Vo-Dinh (ed) CRC

2007

- Biomedical Nanotechnology. N.H.Malsch. Taylor & Francis, 2005.

- Structural DNA Nanotechnology. Nadrian C. Seeman. Cambridge University Press 2016

- Plenty of room for Biology at the bottom: An introduction to Bionanotechnology. E. Gazit. Imperial

College Press 2007

- The Science of Nanotechnology: An Introductory Text . L Tilstra y cols. Nova Science Publishers,

Inc. New York 2008

- BioNanotechnology. Elisabeth S. Papazoglou, Aravind Parthasarathy. Morgan y Claypol, 2007

In-depth bibliography

- Nanobiotechnology. Concepts, Applications and Perspectives. C.M.Niemeyer y C.A. Mirkin(eds.).
Wiley & sons 2004.
- Nanobiotechnology II: More concepts and applications. Chad A. Mirkin and Christof M. Niemeyer
eds) Wiley 2007- Nanobiotechnology. Bioinspired devices and materials of the future. O. Shoseyov y
I Levy. Humana Press, 2008.
- Nanobiotechnology Protocols. S.J.Rosenthal y D.W.Wright. Humana Press 2005.

Journals

Science, Nature, Nature Nanotechnology, Angew.Chem., Langmuir, Nano Lett., Biophysical Journal, Nanotechnology, ACS Nano, Small...

Web addresses

USA National Nanotechnology Initiative. http://www.nano.gov/
European Commision. Nanomedicine Technology Platform. https://etp-nanomedicine.eu/
National Cancer Institute Alliance for Nanotechnolgy in cancer. http://nano.cancer.gov/
blog~nano
Nanoscale Materials and Nanotechnology http://nanoscale-materials-and-nanotechnolog.blogspot.com/search/label/nanomedicine
Nanotechnology Now: http://www.nanotech-now.com/
Responsible Nanotechnology: http://crnano.typepad.com/
Wikipedia -- http://en.wikipedia.org/wiki/Nanotechnology