Advances towards vaccine development: microencapsulation of synthetic peptides and adjuvants for modulating the immune response
- Doctorando/a:
- Aiala Salvador Martínez
- Año:
- 2012
- Universidad:
- Faculty of Pharmacy. University of the Basque Country
- Personas encargadas de la dirección:
- ROSA HERNANDEZ Y MANUELA IGARTUA
- Descripción:
The development of vaccines capable of generating an appropriate immune response remains a challenge for certain diseases. In this work we have prepared some microspheres with a biodegradable and biocompatible polymer, PLGA (poly (lactic-co-glycolic acid), which serve as a release and adjuvant system for synthetic peptides. We have used these microspheres containing beta-amyloid peptide (implicated in Alzheimer's disease) to develop a humoral immune response in mice after intranasal and subcutaneous administration. In addition we have been able to induce combined humoral and cellular responses in mice using model antigens.
- Enlace con información adicional:
- https://www.educacion.gob.es/teseo/mostrarSeleccion.do