Info_PILLAR 2 - HORIZON EUROPE

Pillar 2: Global Challenges and European Industrial Competitiveness

The Global Challenges and European Industrial Competiveness pillar supports research relating to societal challenges and reinforces technological and industrial capacities through 6 CLUSTERS.

It sets EU-missions with ambitious goals tackling some of our biggest problems. More information on Missions is available here.

It also includes activities pursued by the Joint Research Centre which supports EU and national policymakers with independent scientific evidence and technical support.

Social sciences and humanities are fully integrated across all clusters, including specific and dedicated activities.

Pillar II covers activities from a broad range of Technology Readiness Levels (TRLs),
including lower TRLs.

Pillar II holds the lion’s share of the HE programme funding.
 
Pillar II supports research projects carried out by international and inter-disciplinary consortia. The projects address specific pre-defined topics proposed by the EC which fall into six different clusters, each of them focused on specific global societal and industrial challenges. More information on the specific content of each cluster is available by clicking the links below:

  1. Health
  2. Culture Creativity and Inclusive Society
  3. Civil Security for Society
  4. Digital Industry & Space
  5. Climate, Energy & Mobility
  6. Food, Bioeconomy, Natural Resources, Agriculture & Environment

Last modification date: 20/09/2024

Horizon Europe: Pillar 2 projects

SYNAPSING - Synapsing Mental Disorders and Neurodegenerative diseases: Towards more effective diagnosis and management of psychiatric symptoms

Specific programme: HORIZON-HLTH-2024-DISEASE-03-14-two-stage - HORIZON Research and Innovation Actions
UPV/EHU Partner Status: Beneficiary
UPV/EHU PI: Javier Meana

Project start: 01/11/2024
Project end: 31/10/2029

Brief description: Disrupted neuronal connectivity and synapse dysfunction can manifest clinically as a range of emotional, behavioural and cognitive symptoms that are common to, and often overlapping in, mental disorders (MDs) such as major depressive disorder, bipolar disorder and schizophrenia and neurodegenerative disorders (NDs) such as Alzheimer’s disease and Parkinson’s disease.

Antidepressants and antipsychotics used to treat these symptoms are often ineffective in ND patients and treatment-resistance is common in MD patients. To tackle the burden exacted on society by untreated psychiatric symptoms, Synapsing will generate the first trans-European clinical collection of clinical, neuroimaging and socioeconomic data from >3000 patients from MD and ND clinics for use in Synapsing and beyond. Synapsing aims to introduce a biological framework for MDs through a search for blood biomarkers to engender a faster, more objective diagnosis and reduce misdiagnosis with NDs. To minimise the use of inefficient treatments across MDs and NDs, Synapsing will develop blood biomarkers to objectively monitor therapeutic response and to stratify patients who would benefit from therapeutic intervention. To guide the development of more effective treatments, Synapsing will model synapse dysfunction using post-mortem brain tissue and induced pluripotent stem cell derived neurons from MD and ND patients. To prevent social disparities impacting on healthcare, Synapsing will identify modifiable socioeconomic risk factors for psychiatric symptoms in >2000 individuals with a lived experience of mental health issues and MD and ND patients recruited across Europe. Recommendations for evidencebased policy initiatives targeted towards reducing these risk factors will be disseminated to EU council agencies. Expected outcomes include better understanding of these under-researched conditions, revised clinical guidelines to better diagnose and manage patients and strengthened knowledge and care networks.

info_masinformacionehurope

Contact information:

International R&D Office UPV/EHU
Email: proyectoseuropeos@ehu.es

Last modification date: 12/09/2024