HETEROGENEIDAD GENETICA Y PROCESOS DE POBLAMIENTO EN POBLACIONES HUMANAS
	Códigos UNESCO 2402.02, 2402.03, 2409.03 Miembros del grupo Jose A. Peña Miguel A. Alfonso-Sánchez Luis Gómez-Pérez Ibone Espinosa En colaboración con Ana M. Pérez-Miranda Susana García-Obregón Servicio de Investigación Genómica UPV/EHU

En esta línea de trabajo, dedicada a la diversidad del genoma humano y a los procesos de poblamiento y mestizaje, nuestro grupo ha analizado varios polimorfismos genéticos (inserciones Alu, genes HLA, STRs de la región HLA, Y-STRs, CODIS STRs) en diferentes poblaciones. Hemos profundizado en el conocimiento de los factores causales de la diversidad y de la heterogeneidad genética inter e intrapoblacional, considerando especialmente la influencia del flujo génico.
En este contexto, hemos analizado algunos aspectos del poblamiento del continente europeo, de los efectos de las migraciones en la cuenca mediterránea, los procesos de mestizaje en hispanoamérica y posibles alternativas al origen de los vascos.

García-Obregón S, Alfonso-Sánchez MA, Pérez-Miranda AM, Gómez-Pérez L, de Parcorbo MM, Peña JA (2012) Ancestry markers from the human chromosome 6: Alu repeats from the MHC in autochthonous Basques.
Human Immunology http://dx.doi.org/10.1016/j.humimm.2012.04.010

Gómez-Pérez L, Alfonso-Sánchez MA, Sánchez D, García-Obregón S, Espinosa I, Martínez-Jarreta B, De Pancorbo MM, Peña JA (2011) Alu polymorphisms in the Waorani tribe from the Ecuadorian Amazon reflect the effects of isolation and genetic drift.
Am J Hum Biol. 2011 23(6):790-5.

Cardoso S, Alfonso-Sánchez MA, Valverde L, Odriozola A, Pérez-Miranda AM, Peña JA, M. de Pancorbo M (2011) The maternal legacy of Basques in Northern Navarre: New insights into the mitochondrial DNA diversity of the franco-cantabrian area
American Journal of Physical Anthropology DOI 10.1002/ajpa.21532

Gómez-Pérez L, Alfonso-Sánchez MA, Dipierri JE, Alfaro E, García-Obregón S, M. de Pancorbo M, Bailliet G, Peña JA (2011) Microevolutionary processes due to landscape features in the province of Jujuy (Argentina)
American Journal of Human Biology 23:177-184

García-Obregón S, Alfonso-Sánchez MA, Pérez-Miranda AM, Gómez-Pérez L, M. de Pancorbo M, Peña JA (2010) Genetic variability in autochthonous basques from Guipuzcoa: a view from MHC microsatellites
International Journal of Immunogenetics 37: 279-287

Gómez-Pérez L, Alfonso-Sánchez MA, Pérez-Miranda AM, García-Obregón S, Builes JJ, Bravo ML, M. de Pancorbo M, Peña JA (2010) Genetic admixture estimates by alu elements in afro-colombian and mestizo populations from Antioquia, Colombia
Annals of Human Biology 37: 488-500

Alfonso-Sánchez MA, Pérez-Miranda AM, García-Obregón S, Peña JA (2010) An evolutionary approach to the high frequency of the delta F508 CFTR mutation in european populations
Medical Hypotheses 74: 989-992

Cardoso S, Merino M, Gómez-Pérez L, Alfonso-Sánchez MA, Dipierri JE, Alfaro E, Valverde L, Odriozola A, B CM, Peña JA, De Pancorbo MM (2009) Mitochondrial DNA control region in native population from the province of Jujuy (Northwestern Argentina)
Forensic Science International: Genetics Supplement Series 2: 340- 341

Alfonso-Sánchez MA, Cardoso S, Martínez-Bouzas C, Peña JA , Herrera RJ, Castro A, Fernández-Fernández I, De Pancorbo MM (2008) Mitochondrial DNA Haplogroup Diversity in Basques: A reassessment Based on HVI and HVII Polymorphisms.
American Journal of Human Biology 20: 154-164

Cardoso S, Alfonso-Sánchez MA, González-Andrade F, Valverde L, Odriozola A, Pérez-Miranda AM, Peña JA, Martínez-Jarreta B, De Pancorbo MM (2008) Mitochondrial DNA in Huaroni (Ecuadorian amerindians): A new variant in haplogroup A2.
Forensic Science International: Genetics Supplement Series

García-Obregón S, Alfonso-Sánchez MA , Pérez-Miranda AM, Pancorbo MM, Peña JA (2007) Polymorphic Alu insertions and the genetic structure of Iberian Basques.
Journal of Human Genetics 52: 317-327

Gómez-Pérez, L., Alfonso-Sánchez, M.A., Pérez-Miranda, A.M., de Pancorbo, M.M., Peña, J.A., 2007, Utilidad de las inserciones Alu en los estudios de mestizaje
Antropo, 14, 29-36. www.didac.ehu.es/antropo

Peña JA, García-Obregón S, Pérez-Miranda AM, Pancorbo MM, Alfonso-Sánchez MA (2006) Gene flow in the Iberian Peninsula determined from Y-chromosome STR loci
American Journal of Human Biology 18, 532-539

Alfonso-Sánchez MA, Martínez-Bouzas C, Castro A, Peña JA, Fernández-Fernández I, Herrera RJ, de Pancorbo MM (2006) Sequence polymorphisms of the mtDNA control region in a human isolate: The Georgians from Swanetia.
Journal of Human Genetics 51, 429-439

García-Obregón S, Alfonso-Sánchez MA, Pérez-Miranda AM, Vidales C, Arroyo D, Peña JA (2006) Genetic position of Valencia (Spain) in the Mediterranean basin according to ALU insertions
American Journal of Human Biology 18, 187-195

Fernández-Mestre M, Alfonso-Sánchez MA, Gendzekhadze K, Layrisse Z, Peña JA (2006) Genetic polymorphisms at four STR loci from the HLA region in a Venezuelan population
Journal of Forensic Sciences 51, 703-704

Pérez-Miranda AM, Alfonso-Sánchez MA, Peña JA, Herrera RJ (2006) Qatari DNA variation at a crossroad of human migrations
Human Heredity 61, 67-79

Pérez-Miranda AM, Alfonso-Sánchez MA, Kalantar A, Peña JA, de Pancorbo MM, Herrera RJ (2005) Allele frequencies of 13 STR loci in autochthonous basques from the province of Vizcaya (Spain).
Forensic Science International 152, 259-262

Pérez-Miranda AM, Alfonso-Sánchez MA, Kalantar A, García-Obregón S, de Pancorbo MM, Peña JA, Herrera RJ (2005) Microsatellite data support subpopulation structuring among basques.
Journal of Human Genetics 50, 403-414

Pérez-Miranda AM, Alfonso-Sánchez MA, Peña A, de Pancorbo MM, Herrera MJ (2005) Genetic polymorphism at 13 STR loci in autochthonous basques from Alava province (Spain).
Legal Medicine 7, 58-61

Peña, J.A., Alfonso-Sánchez, M.A., Pérez-Miranda, A., García-Obregón, S. (2004) Flujo génico y presiones selectivas en Europa. Una aproximación a partir de clinas de ADN codificante y no codificante.
Antropo 8, 117-122. http://www.didac.ehu.es/antropo/

Pérez-Miranda AM, Alfonso-Sánchez MA, Vidales MC, Calderón R, Peña JA (2004) Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain).
Tissue Antigens, 64: 264-275

Pontes ML, Peña JA, Alfonso-Sánchez MA, Abrantes D, Lima G, Pereira MJ, Fernández-Fernández I, Castro A, Pinheiro MF, de Pancorbo MM (2004) Y chromosome STRs in the North of Portugal.
International Congress Series 1261: 350-352

Lima G, Peña JA, Alfonso-Sánchez MA, Pontes ML, Abrantes D, Pereira MJ, Fernández-Fernández I, Castro A, Pinheiro MF, de Pancorbo MM (2004) Analysis of the HVI and HVII regions of mitochondrial DNA in 100 individuals from North of Portugal.
International Congress Series 1261: 366-368

Pérez-Miranda A, Alfonso-Sánchez M, Peña JA, Calderón R (2003) HLA-DQA1 polymorphism in autochthonous Basques from Navarre (Spain): Genetic position within European and Mediterranean scopes.
Tissue Antigens, 61:465-474

Calderón R, Carrión M, Pérez-Miranda A, Peña JA, Dugoujon JM, Crouau-Roy B (2003) Allele variation of DYS19 and Y-alu insertion (yap) polymorphisms in Basques. An insight into the peopling of Europe and Mediterranean space.
Human Biology, 75: 117-127

Peña JA, Alfonso-Sánchez MA, García-Obregón S, Pérez-Miranda A (2002) Persistencia de actividad lactasa en población residente en el País Vasco.
Antropo, 3:51-60 http://www.didac.ehu.es/antropo/

Peña JA, Alfonso-Sánchez MA, García-Obregón S, Pérez-Miranda A (2002) Aislamiento por distancia en poblaciones europeas sobre la base de polimorfismos genéticos séricos.
Antropo, 2:31-39 http://www.didac.ehu.es/antropo/

Peña JA, Calderón R, Pérez-Miranda A, Vidales C, Dugoujon JM, Carrión M and Crouau-Roy B (2002) Microsatellite DNA markers from HLA region (D6S105, D6S265 and TNFA) in autochthonous basques from Northern Navarre (Spain).
Annals of Human Biology, 29:176-191

Calderón R, Perez-Miranda A, Peña JA, Vidales C, Aresti U, Dugoujon JM (2000) The genetic position of the autochthonous subpopulation of Northern Navarre (Spain) in relation to the other Basque subpopulations. A study based on GM and KM immunoglobulin allotypes.
Human Biology, 72: 619-640

Dipierri JE, Alfaro E, Peña JA, Constans J, Dugoujon JM (2000) GM, KM immunoglobulin allotypes and other serum genetic markers (HP, GC, PI and TF) among South American populations living at different altitudes (Jujuy Province, Argentina): Admixture estimates.
Human Biology, 72:305-319

Martinez-Labarga C, Rickards O, Scacchi R, Corbo RM, Biondi G, Peña JA, Varas de Vieira C, Guevara A, Mesa MS and de Stefano GF (1999) Genetic population structure of two African-american communities of Esmeraldas (Ecuador).
American Journal of Physical Anthropology, 109:159-174

Calderón R, Vidales C, Peña JA, Perez-Miranda A and Dugoujon JM (1998) Immunoglobulin allotypes (GM and KM) in Basques from Spain: Approach to the origin of the Basque population.
Human Biology, 70:667-698

Papiha SS, Calderón R, Sertedaki A, Peña JA, Zhong Y and Chakraborty R (1998) Study of three hypervariable DNA loci (D1S7; D7S22 and D12S11) in three European populations.
Annals of Human Biology, 25(1):29-41

Mastana SS, Calderon R, Peña JA, Reddy PH, Papiha SS (1998) Anthropology of the Apolipoprotein E (Apo E) gene: Low frequency of Apo E4 allele in basques and in tribal (Baiga) populations of India.
Annals of Human Biology, 25:137-143

García Fernández E, Arrieta A, Riñón M, Maruri N, Arranz MC, Peña JA, García Masdevall MD (1997) Genetic polymorphisms of HLA class I and class II system in the Basque population.
Transplantation Proceedings, 29(8):3707-3709

@ 1997-2011, Jose A. Peña