The need for new technology to advance in the field of biomedical research is the driving force of this proposed work. A bibliographic investigation on the current state of nanoplasmonic biosensors for PoC devices was carried out. Thanks to the progress made in the field of nanoplasmonics, nanoplasmonic biosensors based on gold structures have proved to be valid and solid for real-time biosensing. In order to prove this, the general use of plasmonic biosensors and a comparison between PSPR and LSPR will be discussed. Besides, different approaches for a proper fabrication of LSPR sensors and nanoparticle functionalization are addressed, in order to discuss the validity of LSPR sensors for biosensing even at portable user-friendly devices.