Platelet-Rich Plasma, also known as PRP, is an autologous biologic product used in medi-

cine as a treatment for tissue repair. Nowadays, the majority of PRP obtention methods

enrich only platelets, not considering extraplatelet biomolecules, which take part in several

cell processes. In the present work, a novel PRP preparation method was developed to

obtain a PRP rich in both platelet and plasma extraplatelet molecules. The method is based

on the evaporation of the water of the plasma using a rotary evaporator. With this new meth-

odology an increase in plasmatic growth factors and, as a consequence, a better dermal

fibroblast cell viability was achieved, compared to a standard PRP formulation. This novel

PRP product obtained with this new methodology showed promising results in vitro as an

improved PRP treatment in future application