Large Techno-Social (LTS) systems are characterized by the large number of heterogeneous actors and the complexity and emergent character of the processes undertaken in them (Rod and Kera, 2010). They represent a distinctive paradigm in contemporary societies, where advanced technology intertwines intricately with complex social structures, giving rise to multifaceted challenges and opportunities (Vespignani, 2009). These systems have become the cornerstone of modern civilization, and their influence is felt across organizations, sectors, shaping economies, cultures, and political landscapes. Understanding these systems is not merely an academic pursuit, it is rather a pressing societal necessity. This volume delves into the heart of these intricate LTS, providing comprehensive insights into their functioning, challenges, and the imperative solutions and debates required for their sustainable evolution.