In this course, the protocols and the analytical methodology used in the context of industrial chemistry are described. It starts with a description of analytical industrial processes and the analytical needs for the control of processes and products are highlighted. The analytical techniques used in the off-line, at-line, in-line and on-line analysis are described together with the most usual non invasive analytical methods (UV-VIS, NIR, IR, Raman, FIA, Electrochemical and Surface methods, etc.). Process chemometrics is also introduced, including multivariate regression and image analysis. Finally, by means of case studies, the most important applications in industrial processes such as pharmaceutical, metal transformation, food, etc. are described. Some laboratory works are included in this course with the purpose of performing instrumental data treatment.

This course main objective is to develop the Chemistry Degree's Advanced Module specific competence CM06 "Characteristics of industrial processes and analytical needs for the control of processes and products". Other specific competences in this module such as CM04 ("Set up the protocols and quality standards in a chemical laboratory to be able to validate the analytical and measurement methods and to facilitate an adequate management of its resources"), CM15 ("Evaluate, interpret, synthesize and communicate chemical data and information") and CM16 ("Know the structure and organization of legal regulations concerning security and health in activities related to the use chemical products") will also be taken into consideration.



Other than these, the transversal competences of the Chemistry Degree's Advanced Module that will have a weight in this course are CM08 ("Design and plan experiments in an effective way to solve real chemical problems"), CM09 ("Interpret and discuss relevant results derived from experiments and express the conclusions as scientific and technical reports and presentations") and CM11 ("Be able to explain, in an understandable oral and written form, phenomena and processes related to chemistry and similar matters in Basque, Spanish or English languages").



The syllabus of the course includes concepts such as: Industrial laboratories; Off-line, on-line and in-line analysis; Non-invasive instrumental methods (UV-Vis-Nir, IR, Raman, RMN, XRF, etc.); Automated analysis systems; Process chemometrics; Statistical process control; Image analysis;

Case studies and applications in the pharmaceutical, metallurgical, food transformation and waste-water treatment industries.

- Introduction.

- Characteristics of industrial processes.

- Analytical needs and requirements for the control of processes and products.

- Industrial laboratories.

- Process control.

- Description of the analysis methods used in industrial processes: off-line, at-line, on-line, in-line.

- Non-invasive analytical methods. Characteristics of non-invasive methods. Instrumental set-up and analytical characteristics. Application of spectroscopic methods: UV-Vis-Nir, IR, XRF, etc.

- Advanced chemometrics: multivariate classification and regression. Curve resolution methods. Image analysis. Calibration transfer.

- Multivariate statistical control.

- Time series analysis.

- Case studies: Applications in the pharmaceutical, metallurgical, food transformation and waste-water treatment industries.

Legend: M: Class Lectures; S: Seminar; GA: Class Activities; GL: Laboratory Activities; GO: Computer Activities; GCL: Clinic Activities; TA: Workshop; TI: Ind. Workshop; GCA: Field Activities



Notes :

Lab work (GL) assistance is compulsory

• Final Assessment System
• Tools and qualification percentages:
  • Written test to be taken (%): 25
  • Realization of Practical Work (exercises, cases or problems) (%): 15
  • Individual works (%): 30
  • Team projects (problem solving, project design)) (%): 30

In the Ordinary Call, the criteria used to evaluate the students have the following weights:



1 - QUIZZ-LIKE WRITTEN EXAMINATION: 20%

2 - ORAL EXAMINATION: 15%

3 - LABORATORY WORK (DEVELOPMENT AND NOTEBOOK): 20%

4 - INDIVIDUAL AND GROUP ASSIGNMENTS: 25%

5 - PRESENTATIONS, READINGS...: 20%



The minimum mark in each part should be 5/10.



Also, failing to pass with at least a 5/10 in the global of items 3 to 5 (which accounts for the 65% of the course mark) means that the course can not be passed.

In the Extraordinary Call, it is considered that only the students that have a mark of 5/10 in items 3 to 5 in the Ordinary Call can demonstrate that they have acquired the knowledge and competences specific for this course. Thus, only those students that have a mark over 5/10 in the average of items 3 to 5 in the Ordinary Call will be called and will have to perform the exams stated in items 1 and 2 of the above evaluation criteria.



Concerning resignation to these calls, apart from the general procedure established by the academic authorities, students are allowed to communicate it with just 5 days in advance to date of the call.

Laboratory notebook, Laboratory coat, personal safety means (glasses, gloves, etc.), spatula and glass ink marker

Basic bibliography

 - "Process Analytical Chemistry". F.McLennan and B.R.Kowalski. Blackie Academic Professional. New York, 1996.

- "Process Analytical Chemistry : Control, Optimization, Quality,  Economy".Karl-Heinz Koch. Springer-Verlag. N.Y., 1999.

In-depth bibliography

- K.A. Bakeev (Ed.), Process Analytical Technology, Blackwell Publ. Oxford, UK, 2006

Journals

- Journal of Process Analytical Chemistry (http://www.infoscience.com/JPAC/)
- Industrial & Engineering Chemistry (http://pubs.acs.org/loi/iechad)
- Applied Spectroscopy Reviews (http://www.tandf.co.uk/journals/titles/05704928.asp)
- The Open Process Chemistry Journal (http://www.bentham.org/open/tocpcj/index.htm)

Web addresses

- http://www.cpac.washington.edu
- http://www.ifpacnet.org
- http://www.cpact.com
- http://www.analyticjournal.de/aj_navigation/ak_pat.htm
- https://theanalyticalscientist.com/