The subject is Organic Chemistry, a core subject of the first year for the Degree in Human Nutrition and Dietetics and the Degree in Pharmacy. The basic concepts of this field of knowledge are presented, such as nomenclature, structure (isomerism, stereochemistry), and properties and reactivity of simple organic compounds grouped by functional groups.

This subject is fundamental in the Degree in Human Nutrition and Dietetics so that students can understand other subjects of the degree such as Biochemistry, Food Chemistry and Biochemistry, and Culinary Technology and Food Processing. Organic Chemistry is used in the elaboration of additives and food preservation processes and is essential for the future professional Dietician-Nutritionist to understand how food nourishes the body.

For students in the Bachelor's Degree in Pharmacy, the knowledge acquired in the first year will be fundamental for the second year of the subject Extension of Organic Chemistry. In this case, the student must be able to apply the concepts studied in the subject Organic Chemistry in the first year, to understand the structure, properties and reactivity of compounds with various functional groups and heterocycles and their preparation. Subsequently, in the third year of the degree, students will take the subject Pharmaceutical Chemistry, where they will study the types of interaction between different biological targets and organic compounds based on their structure and physicochemical characteristics, in order to be able to predict the biological activity of the compounds, and to know the main methods for the design and synthesis of drugs, one of the possible professional activities of graduates.

Know and apply the terminology and basic concepts of structure and reactivity of organic compounds.

Understand the importance of stereochemistry on the reactivity and biological activity of organic compounds.

Study in depth each functional group and know the interconversions of some functional groups into others.

Predict and interpret the reactivity of different organic compounds.

Formulate the mechanisms of the most representative organic reactions.

Acquire a solid base to be able to tackle more complex synthetic processes in organic chemistry.

Be able to work in a team in the practical laboratory and in the classroom practice.

LEARNING OUTCOMES

- The student names and formulates any organic compound using systematic nomenclature.

- The student applies the terminology used in organic chemistry.

- The student determines the stereochemistry of organic compounds.

- The student formulates interconversion reactions between functional groups.

- The student predicts the reactivity of organic compounds under certain reaction conditions as well as the mechanisms of the most representative organic reactions

1.- ALKANES AND CYCLOALKANES

Linear and branched alkanes. Properties of alkanes. Conformational study of saturated structures. Reactions of alkanes. Industrial source. Cycloalkanes.

2.- STEREOISOMERISM

Introduction. Concept of chirality. CIP standards. Molecules with two asymmetric carbon atoms. Fischer projections. Separation of a mixture of enantiomers. Stereochemistry in organic reactions.

3.- ALKENES

Structure and physical properties of alkenes. Relative stability of alkenes. Preparation of alkenes. Reactions of alkenes. Alkenes in nature. Dienes

4.- ALKYNES

Structure and properties of alkynes. Preparation of alkynes. Reactions of alkynes. Alkynes of interest.

5.- BENZENE AND ITS REACTIONS. Part I

Aromatic hydrocarbons. Structure of benzene. Reactions of benzene: Aromatic electrophilic substitution. Halogenation, nitration, sulphonation, alkylation and acylation.

6- BENZENE AND ITS REACTIONS. Part II

Electrophilic aromatic substitution in substituted benzenes. Speed and orientation of the reactions. Oxidation of benzene and its derivatives.

7- HALOGENATED DERIVATIVES

Structure and physical properties of halogenated derivatives. Synthesis methods and applications. Reactions of halogenated derivatives. Nucleophilic substitution and elimination. Organometallic compounds.

8- ALCOHOLS, ETHERS

Structure and physical properties of alcohols. Methods of synthesis of alcohols. Strategies to obtain complex alcohols. Reactions of alcohols. Phenols. Structure and physical properties of ethers. Methods of ether synthesis. Ether reactions.

9- ALDEHYDES AND KETONES

Structure and physical properties of carbonylic compounds. Methods of synthesis. Reactivity in the carbonyl group, Additions, Reduction, Oxidation.

10- CARBOXYLIC ACIDS

Structure and physical properties of carboxylic compounds. Methods of synthesis. General reactivity. Addition-elimination mechanism.

11- CARBOXYLIC ACID DERIVATIVES.

Acid halides, anhydrides, esters, amides. Physical properties and methods of synthesis. Comparative study of their reactivity. Reactions of each of the functional groups. Nitriles.

12- AMINES.

Structure and physical properties of amines. Synthesis methods. Most important reactions of amines.



PRACTICE PROGRAMME

1.- Purification of solid compounds. Crystallisation. Sublimation.

2.- Purification of liquid compounds: Distillation.

3.- Solvent extraction

4.- Thin layer chromatography.

5.- Acetylation reactions.

6.- Identification of functional groups in organic compounds.

Teaching is given through the modalities of Master Class, Classroom Practicals and Laboratory Practicals.

During the Master Classes the different topics are presented, and the basic principles of the subject will be taught.

In the Practicals Classes, exercises and problems related to these contents are posed and solved, individually or in groups, which allows a better understanding of them through their practical application.

In the Practicals in Laboratory, students work on the basic techniques of an organic chemistry laboratory. In addition, these techniques are applied in the synthesis of some compounds and in the practical recognition of different functional groups.

• Continuous Assessment System
• Final Assessment System
• Tools and qualification percentages:
  • Written test to be taken (%): 75
  • Multiple-Choice Test (%): 15
  • Realization of Practical Work (exercises, cases or problems) (%): 10

Two modalities of evaluation are established: continuous and final assessment.

1) Modality I (continuous assessment).

- Attendance at all sessions of the laboratory practicals is mandatory: completion, handing in the work sheets and a practical exam (according to the official calendar of the Faculty): (10%).

- Three written self-assessment/control tests: (30%). In order for this mark to be considered in the final grade, the student must pass 70% in each of the tests and attend at least 80% of the face-to-face activities.

- Ordinary written final exam (60%). In order for the practicals calification to be added, it is necessary to obtain a minimum of 40% in the final exam and demonstrate a minimum knowledge of the parts (according to the official calendar of the Faculty).

1) Modality II (final assessment).

- Completion of the laboratory practicals is compulsory: handing in the work sheets and a practical exam (according to the official calendar of the Faculty): (10%).

- Ordinary written final exam (90% of the grade). In order for the practicals calification to be added up, it is necessary to obtain a minimum of 40% in the final exam and to demonstrate a minimum knowledge of the parts (according to the official calendar of the Faculty).



In any case, whether students take the tests associated with the continuous assessment or the final assessment, they must provide evidence of THE ACQUISITION OF BOTH THEORETICAL AND PRACTICAL SKILLS.



According to the UPV/EHU evaluation regulations, non-attendance at the final assessment tests, both in the ordinary and extraordinary exams, will mean that the final grade for the subject will be No Show.

Students who completed the laboratory practicals but do not pass the course will have their marks kept for one academic year (if it is higher than 0.5 points) although in the following academic year they will also have the right to do the corresponding practicals, always attending 100% of the hours (except in cases of major circumstances).



Academic ethics protocol

During the development of the assessment tests, the use of books, notes, as well as telephonic, electronic, computerised or any other type of devices by students will be prohibited.. In the event of any case of dishonest or fraudulent practice, the provisions of the protocol on academic ethics and prevention of dishonest or fraudulent practices in assessment tests and academic work at the UPV/EHU will be applied.

If the student does not pass the course in the ordinary exam call, he/she may sit in the extraordinary call, where the final assessment system will be applied.

- Compulsory completion of the laboratory practicals: handing in the work sheets and a practical exam (according to the official calendar of the Faculty): (10%).

- Extraordinary final written exam (90% of the grade). In order for the practicals to be added up, it is necessary to obtain a minimum of 40% in the written final exam and to demonstrate a minimum knowledge of the parts (according to the official calendar of the Faculty).

According to the UPV/EHU evaluation regulations, non-attendance at the final extraordinary assessment exams will mean that the final grade for the subject will be No Show.



Academic ethics protocol

During the development of the assessment exams, the use of books, notes, as well as telephonic, electronic, computerised or any other type of devices by students will be prohibited.. In the event of any case of dishonest or fraudulent practice, the provisions of the protocol on academic ethics and prevention of dishonest or fraudulent practices in assessment tests and academic work at the UPV/EHU will be applied.

Lab coat and security glasses

Basic bibliography

Basic bibliography

-Wade LG. Química Orgánica 5ª Edición. Pearson Prenticell; 2004.

-Vollhardt PC, Schore NE. Química Orgánica 5ª Edición. Barcelona: Ediciones Omega, S. A.; 2008.

-Hart H, Craine L, Hart D, Hadad C. Química Orgánica 12ª Edición. Mexico: McGraw-Hill; 2007.



Nomenclature Books:

- Peterson WR. Formulación y Nomenclatura Química Orgánica 8ª Edición. Barcelona: Eunibar; 1986.

- Peterson WR. Introducción a la nomenclatura de las sustancias químicas. Barcelona: Reverté; 2010.

- Quiñoa E. Nomenclatura y representación de los compuestos orgánicos Madrid: McGraw-Hill-Interamericana; 2005.

In-depth bibliography

- Clayden J, Greeves N, Warren S, Wothers P. Organic Chemistry. Oxford: Oxford University Press; 2001.
- Ege S. Química Orgánica Vol. 1. Barcelona: Reverté; 1997.
- Morrison RT, Boyd RN. Química Orgánica 5ª Edición. USA: Addison-Wesley Iberoamericana; 1990.
- McMurry J. Química Orgánica 7ª Edición. Mexico: Thomson Paraninfo; 2009.
- Streitwieser A, Heathcock CH. Química Orgánica 3ª Edición. Madrid: Interamericana; 1986.

Journals

The Journal of Organic Chemistry. Available at URL: https://pubs.acs.org/journal/joceah (Accessed date May 20th, 2024)
Chemical Reviews. Available at URL: http://pubs.acs.org/journal/chreay; (Accessed date May 20th, 2024)
Jounal of the American Chemical Society. Available at URL: http://pubs.acs.org/journal/jacsat; (Accessed date May 20th, 2024)
Organic Letters. Available at URL: http://pubs.acs.org/journal/orlef7; (Accessed date May 20th, 2024)
Tetrahedron. Available at URL: https://www.sciencedirect.com/journal/tetrahedron; (Accessed date May 20th, 2024)
Tetrahedron Letters. Available at URL:
https://www.sciencedirect.com/journal/tetrahedron-letters; (Accessed date May 20th, 2024)

Web addresses

Introducción química orgánica. Available at URL:
http://www.chem.ox.ac.uk/vrchemistry/OrgCompounds/HTML/page01.htm
Accessed date May 20th, 2024.
Tutoriales: química orgánica, reactividad. Available at URL: http://www.chem.uiuc.edu/weborganic/organictutorials.htm
Accessed date May 20th, 2024.
Tutoriales: nomenclatura, ejercicios, reacciones, síntesis. Available at URL: http://chemistry.boisestate.edu/richardbanks/
Accessed date 20-05-2024.
Varios recursos: bibliografía, síntesis, reactividad, espectroscopia, tutoriales. Available at URL: http://www.organicworldwide.net/
Accessed date May 20th, 2024.
Varios recursos: nomenclatura, modelos moleculares, animaciones, orbitales, espectroscopia, estereoisomería, riesgos toxicológicos. Available at URL: http://chemconnections.org/general/chem121/web07.html
Accessed date May 20th, 2024.
Programa gratuito de representación de moléculas ChemSketc. Available at URL:
http://www.acdlabs.com/download/chemsk.html
Accessed date May 20th, 2024.
Tabla periódica interactiva. Available at URL: http://www.webelements.com/index.htm
Accessed date May 20th, 2024.
Nomenclatura. Available at URL: http://www.chem.qmul.ac.uk/iupac/
Accessed date May 20th, 2024.
Animaciones (orbitales, estereoquímica, reacciones. Available at URL:
http://www.colby.edu/chemistry/OChem/demoindex.html
Accessed date May 20th, 2024.
Reacciones y animaciones en 3-D. Available at URL: http://wetche.cmbi.ru.nl//organic/
Accessed date May 20th, 2024.
Química Orgánica, síntesis, reactividad, espectroscopia. Available at URL: http://guest.portaportal.com/mrchemistry
Accessed date May 20th, 2024.