M1.2. Know the chemical and physical foundations that determine the properties of biological molecules and govern the reactions in which they participate.

M01CM1.3. Correctly formulate any inorganic or organic compound of biological relevance and/or biotechnological application and identify its functional groups and its behavior in aqueous and non-aqueous solutions.

M01CM1.4. Adequately describe the different types of chemical bonds, as well as the structure, nomenclature and reactivity of the main organic compounds

Topic 1: Introduction to organic chemistry.



Topic 2: Structure and bond in organic compounds.

2.1. Centesimal, empirical and molecular formulas.

2.2. Formulation and nomenclature of organic compounds.

Concept of functional group and homologous series.

2.3. Lewis structures. Formal charges.

2.4. Atomic orbitals.

2.5. The carbon atom. Hybridizations and links.



Topic 3: Molecular structure and properties.

3.1. Bond polarity and polarity of molecules.

3.2. Intermolecular attractions and repulsions.

3.3. Structure and physical properties.

3.4. Steric effects and electronic effects.

3.5. Resonant effect.

3.6. Acidity and basicity.



Topic 4: Stereochemistry.



Topic 5: Perspective of organic reactions.

5.1. Types of organic reactions.

5.2. Reaction mechanisms.

5.3. Thermodynamics and kinetics of organic reactions.

5.4. Energy profile of a reaction.

5.5. Reaction intermediates.





Topic 6: Alkenes.

6.1. Physical properties of alkenes.

6.2. General reactivity of alkenes.

6.3. Catalytic hydrogenation.

6.4. Halogenation.

6.5. Addition of hydrogen halides.

6.6. Adding water.

6.7. Epoxidation.

6.8. Dihydroxylation.



Topic 7. The nucleophilic substitution reaction and the elimination reaction.

7.1. Halide reactivity

7.2. Reactivity of alcohols

7.3. Reactivity of ethers

7.4. Amines reactivity



Topic 8. The addition reaction to a carbonyl group.

Joint study of the reactivity of aldehydes and ketones.





Topic 9. The nucleophilic substitution reaction on an acyl group.

Joint study of the reactivity of carboxylic acids and their derivatives.





Topic 10: Alkanes and cycloalkanes.

10.1. Properties of alkanes.

10.2. Reactivity of alkanes. Combustion. Radical halogenation.

The first part of the syllabus tries to review and deepen, to the appropriate extent, concepts that the student has acquired in the subject "Chemistry" that they took in the first year of the Degree.

In the development of the program, special attention will be paid to illustrating structural and reactivity concepts using simple biomolecules as examples and, in parallel, trying to highlight the conceptual similarities between processes specific to organic chemistry and processes established for different metabolic routes.

This subject consists of 29 hours of master class and 16 hours of classroom practices. In classroom practices, exercises, questions and problem solving will be carried out.

CONTINUOUS ASSESSMENT:



- Final exam: it will represent 70% of the final grade.

- Completion of group work: it will represent 15% of the final grade.

- Resolution of exercises and classroom tasks: it will account for 15% of the final grade.

The minimum grade for each section will be 4.0 points.



The evaluation criteria will be the following:

- Correct formulation of the issues.

- Accuracy and consistency in responses.



Note:

To benefit from this evaluation system, the student must complete the proposed work and exercises.



Resignation:

The student who wishes to waive the continuous evaluation, and therefore opt for the final evaluation, must indicate this in writing to the teacher before week 9 from the beginning of the second semester.



FINAL EVALUATION:



Written exam: 100% of the final grade.



Resignation:

It will be enough to not take the final exam to renounce the ordinary call.



During the development of the evaluation tests, the use of books, notes or notes, as well as telephone, electronic, computer, or other devices or devices by students, will be prohibited. In any case of dishonest or fraudulent practice, the provisions of the protocol on academic ethics and prevention of dishonest or fraudulent practices in evaluation tests and academic works at the UPV/EHU will be applied.

There is no mandatory material.

Basic bibliography

- BORRELL, J.I.; TEIXIDÓ, J.; FALCÓ. "Síntesis orgánica". Síntesis, Madrid, 1999.

- CARDA, M.; RODRÍGUEZ, S.; GONZÁLEZ, F.; MURGA, J.; FALOMIR, E.; CASTILLO, E. "Síntesis orgánica. Resolución de problemas por el método de desconexión". Publicaciones de la Universitat Jaume I, Castellón, 1996

- TERRETT N. K. "Química combinatoria". Díaz de Santos S. A., Ediciones 2001

In-depth bibliography

- SENECI P., "Solid-Phase Synthesis and Combinatorial Technologies", Wiley & sons, Chisester 2000
- WARREN, S. "Organic synthesis. The disconnection approach". Wiley & sons, Chisester, 1999.
- GAWLEY, R. E.; JEFFREY, R. E. "Principles of asymmetric synthesis". Pergamon, Londres, 1996
- NICOLAU, K. C.; SORENSEN, E. J. "Classics in total synthesis: targets, strategies, methods". VCH, Weinheim, 1996
- NICOLAU, K. C. "Classics in total synthesis ii: more targets, strategies, methods". VCH, Weinheim, 2003.
- COREY, E.J.; CHENG, X.-M. "The logic of chemical synthesis". Wiley & sons, Nueva York, 1995.

Journals

- The Journal of Chemical Education: http://jchemed.chem.wisc.edu/
- Organic Syntheses: http://www.orgsyn.org/
- The Journal of Organic Chemistry: http://pubs.acs.org/journal/joceah
- Organic Letters: http://pubs.acs.org/journal/orlef7
- European Journal of Organic Chemistry: http://www3.interscience.wiley.com/journal/27380/home
- Tetrahedron: http://www.sciencedirect.com/science/journal/00404020
- Organic and Biomolecular Chemistry: http://www.rsc.org/Publishing/Journals/Ob/Index.asp¿