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ES36_Biopolymeric materials (BIOMAT)_Koro de la Caba

Koro de la Caba

943017188

koro.delacaba@ehu.eus

https://www.ehu.eus/biomat

Group description

The main research lines of BIOMAT group address various aspects of biopolymeric materials from the extraction of raw materials to the end of life of products.

1. Valorization of industrial by-products or bio-wastes to obtain raw materials
Bio-wastes that are abundant and available at a local scale are selected to extract proteins and polysaccharides. BIOMAT has expertise in the extraction of polysaccharides from marine derived bio-waste, such as algae or squid pens. Proteins such as collagen are extracted from skins and are treated to preserve the triple helix structure of collagen, providing the material with excellent mechanical properties. Other by-products from dairy products and poultry industries, such as sheep wool and chicken feathers, are also employed to obtain proteins.

2. Modification of biopolymers to improve functional properties
After selecting those bio-wastes that can lead to the production of biopolymers with a high yield through sustainable processes, biopolymers are blended or modified to achieve the properties required for each specific application. The incorporation of natural GRAS (generally recognized as safe) additives into the formulations leads to modified materials with improved properties, facilitating the material processing and/or acting as bioactives, with great potential in food and bio-sanitary sectors.

3. Optimization of processing conditions and methods to manufacture bio-based products
Conventional manufacture processes, such as solution casting and compression molding, are employed but also more innovative technologies, such as electrospinning and 3D printing, are optimized to produce 2D and 3D porous structures, respectively. The combination of both techniques to produce novel porous products is also assessed. Rheological analyses are essential for determining the optimal processing conditions. Additionally, the products developed are characterized in order to analyze their viability for the different applications (e.g. active films for food packaging or bioactive-controlled release, membranes for batteries or water filtration, and scaffolds for tissue engineering).

4. Environmental assessment of developed products and involved processes
Life cycle analysis (LCA) is carried out according to ISO 14040 guidelines and recommendations. The identification of the activities or stages that cause environmental impacts and the analysis of the opportunities that the developed products can offer to reduce their environmental load is one of our goals. The data related to the raw materials extraction and product manufacture is collected when processing the products. The consumed and emitted flows, such as raw materials and energy consumption and emissions to air, water, and soil, are considered over the whole life cycle of the products in order to measure their impacts and quantify the contribution of each flow to the damage caused directly to human health, ecosystem quality, and resources.

Keywords

  • Biopolymers
  • Proteins
  • Polysaccharides
  • Polymer processing
  • 3D printing
  • Inks
  • Films
  • Scaffolds
  • Material characterization
  • Environmental assessment

Team Description

  • Koro de la Caba (Principle Investigator)

    ORCID: 0000-0002-8866-7314

  • Pedro Guerrero (Research staff)

    ORCID: 0000-0002-9785-7048

  • Itsaso Leceta (Research staff)

    ORCID: 0000-0002-8154-8021

  • Marta Urdanpilleta (Research staff)

    ORCID: 0000-0002-4078-8184

  • Miriam Peñalba (Research staff)

    ORCID: 0000-0003-2698-0556

  • Sara Cabezudo (Research staff)

    ORCID: 0000-0001-7591-4120

  • Alaitz Etxabide (Post-Doctoral Researcher)

    ORCID: 0000-0002-8025-0717

  • Jone Uranga (Post-Doctoral Researcher)

    ORCID: 0000-0002-0283-1022

  • Aitor Tejo (Post-Doctoral Researcher)

    ORCID: 0000-0003-2693-3696

  • Mireia Andonegi (Post-Doctoral Researcher)

    ORCID: 0000-0001-7250-3051

Projects

  • International network on ionic liquid deep eutectic solvent based metal organic frameworks mixed matrix membranes

    Pl: Roberto Fernández de Luis

    Funding Agency*: EU

    Ongoing: yes

    Project reference: H2020_MSCA-RISE17/05

  • Development of innovative and sustainable electroactive materials for energy storage and tissue engineering

    Pl: Koro de la Caba

    Funding Agency*: NAT

    Ongoing: yes

    Project reference: PID2021-124294OB-C22

  • Investigación en tecnologías de soporte para bioimpresión 4D intraoperatoria de injertos de precisión personalizados

    Pl: Koro de la Caba

    Funding Agency*: RE

    Ongoing: yes

    Project reference: KK-2022/00019

  • Investigación en materiales y procesos biobasados para la estrategia de bioeconomía de Euskadi

    Pl: Koro de la Caba

    Funding Agency*: RE

    Ongoing: yes

    Project reference: KK-2021/00131

* INT - International EU - European NAT - National RE - Regional

Publications

  • A. Irastorza, I. Zarandona, M. Andonegi, P. Guerrero, K. de la Caba, The versatility of collagen and chitosan: from food to biomedical applications, Food Hydrocolloids, 2021
    https://doi.org/10.1016/j.foodhyd.2021.106633

  • J. Uranga, A. Etxabide, S. Cabezudo, K. de la Caba, P. Guerrero, Valorization of marine-derived biowaste to develop chitin/fish gelatin products as bioactive carriers and moisture scavengers, Science of the Total Environment, 2020
    https://doi.org/10.1016/j.scitotenv.2019.135747

  • K. de la Caba, P. Guerrero, T.S. Trung, M. Cruz-Romero, J.P. Kerry, J. Fluhr, M. Maurer, F. Kruijssen, A. Abalat, S. Bunting, S. Burt, D. Little, R. Newto, n From seafood waste to active seafood packaging: An emerging opportunity of the circular economy, Journal of Cleaner Production, 2019
    https://doi.org/10.1016/j.jclepro.2018.09.164

  • A. Etxabide, R.D.C. Ribeiro, P. Guerrero, A.M. Ferreira, G.P. Stafford, K. Dalgarno, K. de la Caba, P. Gentile, Lactose-crosslinked fish gelatin-based porous scaffolds embedded with tetrahydrocurcumin for cartilage regeneration, International Journal of Biological Macromolecules, 2018
    https://doi.org/10.1016/j.ijbiomac.2018.05.154

  • T. Garrido, A. Etxabide, K. de la Caba, P. Guerrero, Versatile soy protein films and hydrogels by the incorporation of β-chitin from squid pens (loligo sp.), Green Chemistry, 2017
    https://doi.org/10.1039/C7GC02982A

Research Lines

ADVANCED MATERIALS AND PROCESSES

Lithium-ion batteries represent the most suitable energy storage systems for a wide range of applications, including small electronic devices. The most used polymers for the development of battery separator membranes are polyolefins, mainly poly(vinylidene fluoride) (PVDF). In this regard, electroactive films based on natural polymers show huge potential, based on their active response but also on their tailorable mechanical, thermal, and chemical properties, as well as versatility with respect to the processing techniques, including 3D printing. Ink formulation and rheological behavior have a critical role in the printability of the materials. This technique is being applied for the development of electrodes, but the processing of the separator membrane by 3D printing has been scarcely explored; therefore, this is a challenge to be addressed.

Active films for pharmaceutical applications, such as bioactive delivery or wound healing, require biocompatibility, water retention capacity, and mechanical strength. Materials based on proteins and polysaccharides can be tailored to achieve the required properties. These films permit the water vapor diffusion and, at the same time, serve as a barrier to bacteria. Specific interactions, such as electrostatic interactions between proteins and polysaccharides, lead to the formation of polyelectrolyte complexes, which are able to respond to specific factors and release bioactives in a sustained manner.

Oxidation is one of the processes that causes food degradation, decreasing food shelf life and leading to food losses. Oxygen is responsible for many degradation processes in food, such as lipid oxidation, but also for microbial growth. In contrast to common plastic packaging, films based on proteins and polysaccharides show excellent oxygen barrier properties and, thus, film-forming formulations and processing conditions can be optimized to meet other required functional properties for active packaging films. In this sense, material characterization is carried out to correlate properties and structure. It is worth noting that considerable financial savings could be made through extending food shelf life and reducing food losses.

SUSTAINABLE MANUFACTURING

The aim of this research line is the replacement of synthetic hydrogels by natural hydrogels for the development of bioinks for 3D printing by extrusion-based methods in order to manufacture scaffolds. BIOMAT group works on 3D printing combined with electrospinning for the development of multilayer scaffolds. Novel products based on biopolymers are designed for different applications, demonstrating the versatility of the biopolymers as a function of the formulation composition and the manufacture type and conditions used. Additionally, the environmental load associated to the manufacture of products is analyzed. Environmental assessment is carried out to calculate environmental impacts and make the corresponding decisions in order to minimize them.