Comparison of the in vitro activity of echinocandins against Candida albicans, Candida dubliniensis, and Candida africana by time–kill curves

Os dejo el resumen de nuestro trabajo científico publicado en Diagnostic Microbiology and Infectious Diseases sobre la actividad de los fármacos antifúngicos denominados equinocandinas contra Candida albicans y dos especies relacionadas estrechamente con esta, Candida africana y Candida dubliniensis. Felicito a mis colegas Sandra Gil-Alonso, Nerea Jauregizar y Elena Eraso de la Facultad de Medicina de la Universidad del País Vasco (UPV/EHU) en Bilbao y Emilia Cantón del Hospital La Fe (Valencia), por su arduo trabajo.

El trabajo completo se puede obtener de forma gratuita durante los próximos días en la página de la revista Diagnostic Microbiology and Infectious Diseases.

Este es su Resumen:

Candida albicans remains the most common fungal pathogen. This species is closely related to 2 phenotypically similar cryptic species, Candida dubliniensis and Candida africana. This study aims to compare the antifungal activities of echinocandins against 7 C. albicans, 5 C. dubliniensis, and 2 C. africana strains by time–kill methodology. MIC values were similar for the 3 species; however, differences in killing activity were observed among species, isolates, and echinocandins. Echinocandins produced weak killing activity against the 3 species. In all drugs, the fungicidal endpoint (99.9% mortality) was reached at ≤31 h with ≥0.5 μg/mL for anidulafungin in 4 C. albicans and 1 C. dubliniensis, for caspofungin in 1 C. albicans and 2 C. dubliniensis, and for micafungin in 4 C. albicans and 1 C. dubliniensis. None of echinocandins showed lethality against C. africana. Identification of these new cryptic species and time–kill studies would be recommendable when echinocandin treatment fails.

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