Usuario:Maitelasarte

María Teresa García Sebastián

Doctora en Ingeniería Informática (Diciembre 2009) // PhD in Computer Science, University of the Basque Country (December 2009).

Ing. Sup. en Informática (Junio 2005) // Engineer in Computer Science (June 2005).

Universidad del País Vasco // University of the Basque Country.

Grupo de Inteligencia Computacional // Computational Intelligence Group.

Dpto. Ciencias de la Computación e Inteligencia Artificial // Computer Science and Artificial Intelligence department.

Tesis // Thesis

Title Contributions to Brain MRI Processing and Analysis

ISBN 978-84-9860-330-9

PhD Advisor: Prof. Manuel Graña Romay (UPV/EHU)

Facultad de Informática (UPV/EHU). December 11, 2009.

Slides

Abstract

This PhD Thesis work has been devoted to several aspects of the processing of medical images based on the Magnetic Resonance Imaging (MRI) technology. The work have been performed pursuing several lines of research that are somehow orthogonal. We started working on MRI denoising, removing intensity inhomogeneity effects. Then we have shifted our attention to the study of Alzheimer’s disease and its detection on structural MRI (sMRI). We have explored the application of statistical and Artificial Neural Networks classifiers to feature vectors extracted in an specific way from the sMRI brain volumes. Finally, we have explored the application of novel computational algorithms proposed by our research group to the analysis of functional MRI (fMRI). These latter techniques fall in the category of Lattice Computing algorithms, and our aim was to show that they can, at least, perform as well as other statistical techniques for the detection of activation patterns.

Áreas de Investigación // Research Areas

Análisis de imágenes de Resonancia Magnética (MRI, fMRI, DTI)// Analysis of MR data (MRI, fMRI, DTI).

Neuroimagen, enfermedades neurodegenerativas // Neuroimaging, Neurodegenerative diseases.

Publicaciones // Publications

• Libros y monografías editadas // Edited Books

• Libros // Books

• Revistas // Journals

• Capítulos de Libro // Book chapters

Herramientas de trabajo // Working Tools

Bases de datos // Databases

• Alzheimer's Disease (sMRI and clinical data)

  ADNI, Alzheimer's Disease Neuroimaging Initiative [1]

  The Open Access Series of Imaging Studies (OASIS)[2]

• Myotonic Dystrophy type 1 (sMRI, DTI and clinical data)

  Experimental Unit and Osatek-Donostia. Donostia Hospital, San Sebastian, Spain

• Facioscapulohumeral Dystrophy (sMRI, DTI and clinical data)

  Experimental Unit and Osatek-Donostia. Donostia Hospital, San Sebastian, Spain

• Normal Brain Database (sMRI, fMRI, DTI)

  BrainWeb: Simulated Brain Database[3]

  The Internet Brain Segmentation Repository (IBSR)[4]

  The fMRI Data Center (fMRIDC)[5]

  DTMRI Data, (a link to Susumu Mori's Lab at Johns Hopkins) [6].

Software

• Matlab [7]

  NIfTImatlab (New York University Center for Brain Imaging) [8]

  SPM5, SPM8 [9], [10]

  WFU_Pickatlas [11]

  Talairach Daemon [12]

  xjView [13]

• FSL[14]
• OSIRIX [15]
• LONI Inspector [16]
• MRIcron [17]

  dcm2nii [18]

• Weka [19]
• SPSS [20]

Proyectos // Research projects

• Participación

Diputación Foral de Guipúzcoa 2006

Aportaciones al diagnóstico de Esclerosis Múltiple mediante el análisis de imagen de Resonancia Magnética [21]

SAIOTEK 2008

Desarrollo de métodos y técnicas de análisis de imagen de resonancia magnética cerebral en el ámbito del software libre para estudio de enfermedades neurodegenerativas (BRAINER) [22]

SAIOTEK 2009

Desarrollo basado en software libre de técnicas morfométricas de anatomía computacional para estudio de enfermedades neurodegenerativas (SOFLIMRI) [23]

Otros proyectos del grupo [24]

• Dirección

Diputación Foral de Guipúzcoa 2007

Detección preclínica del Alzheimer mediante Neuroimagen [25]

SAIOTEK 2007

Desarrollo de técnicas de análisis de imágenes de Resonancia Magnética con aplicación en el diagnóstico preclínico de la enfermedad de Alzheimer [26], [27]

Artículo aceptado. Clasificador de sujetos control y sujetos en las primeras etapas de la EA [28]

Estancias // Stays in foreign centers

(2008) University of West of Scotland, School of Computing, August-October.

Paisley (Scotland, UK).

Charlas y conferencias

• Works on automatic segmentation of Magnetic Resonance Images of the Human Brain Paisley, University of West Scotland, 08-10-2008.

• Resonancia Magnética cerebral para detectar diferencias estructurales entre pacientes con Alzheimer y sujetos sanos (SPM5, VBM) Donostia-San Sebastián, Facultad de informática (UPV/EHU), Laboratorio de Visión por Computador I, 01-12-2008.

Otras actividades // Other activities

Local organizing committee

(2010) The 5th International Conference on Hybrid Artificial Intelligence Systems (HAIS'2010)

(2007) The 9th International Work-Conference on Artificial Neural Networks (IWANN'2007)

Revisor/Reviewer

(2011) IEEE Transactions on Medical Imaging

International review committee / International programme committee

(2010) The International Conference on Neural Computation (ICNC'2010)

(2010-2011) The 5th International Conference on Hybrid Artificial Intelligence Systems (HAIS'2010,2011)

(2010) The 6th International Workshop on Artificial Neural Networks and Intelligent Information Processing (ANNIIP'2010)

(2009-2010) The 10th,11th International Conference on Intelligent Data Engineering and Automated Learning (IDEAL'2009,2010)

(2007-2011) The 9th-11th International Work-Conference on Artificial Neural Networks (IWANN'2007,2011)

(2007-2009) The 11th-13th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems (KES'2007-2009)

Semana de la ciencia

(2007-2009) VII-IX Semana de la Ciencia, la Tecnología y la Innovación, Donostia-San Sebastián.

Asistencia a cursos // Attendance at courses

(2010) FSL & FreeSurfer Course.

Heidelberg, Germany

(2008) Summer School, Mathematics in Brain Imaging.

Institute for Pure & Applied Mathematics, University of California (UCLA), Los Angeles.

(2007) Introducción a la RMN de Alta Resolución.

Servicio General de RMN, Facultad de Ciencia y Tecnología (UPV/EHU), Bilbao.

(2007) Avances en Patología Vascular Cerebral.

Cursos de Verano (UPV/EHU), Donostia-San Sebastián.

Links de interés

• Bases de Datos

• Orientación

• Formatos de imagen

• Conversor entre formatos de imágenes médicas

• Software

• Atlas y plantillas

• fMRI and ICA

• Voxel Based Morphometry (VBM) / SPM

• Información sobre el cerebro

• Imaging Wiki [29]

• Alzheimer's disease

• Libros

• Bibliografía

Datos contacto

E-mail: mgarcia.sebastian@gmail.com

Tfno. // Phone number: (+0034) 943 01 5106

Fax: (+0034) 943 01 5590

Glosario de términos y abreviaturas

Informes internos y drafts

Estado burocrático de la tesis

Facultad de Informática UPV/EHU. 11 diciembre 2009. Sobresaliente cum laude por unanimidad.